Wound-healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model: Wound healing effect of EGC membrane
Open accessAbstract
Centella asiatica (CA) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. This study demonstrated that CA extract facilitates the wound-repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity. Gelatin nanofibres containing C. asiatica extract were fabricated via electrospinning and were shown to exhibit dermal wound-healing activity in a rat model. The wound areas of rat skin treated with electrospun gelatin membranes containing C. asiatica (EGC) presented the highest recovery rate compared with those treated with gauze, neat gelatin membranes and commercial wound dressings. The results of the histopathological examination support the outcome of the wound models. Contact-angle and water-retention measurements confirmed that the addition of C. asiatica extract did not significantly affect the hydrophilicity of the EGC membranes. The measured weight loss revealed that the EGC membranes are biodegradable. The findings suggest that EGC membranes are a promising material for the treatment of skin wounds. Copyright © 2015 John Wiley & Sons, Ltd.
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The intensified effect of nanoencapsulated C. asiatica could be observed even when the nano-capsules contained a 30% lower amount of the compound than the control.
“This intensified effect could be observed even when the nano-capsules contained a 30% lower amount of the compound than the control [52].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [52]
Section 3.5 reports better wound recovery with Centella asiatica–containing electrospun membranes than with gauze (the control). It does not report nanocapsules or an effect achieved with 30% less compound than the control; the control was gauze, not a formulation containing the compound. (LLM, conf=0.86)
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References 29 · Cited by 151
Research works printed but not linked: 1
- Rieger KA, Birch NP, Schiffman JD. 2013; De- signing electrospun nanofibre mats to pro- mote wound healing -a review. J Mater Chem B 1: 4531-4541
- Authors
- Yao, C.-H., Yeh, J.-Y., Chen, Y.-S., Li, M.-H., & Huang, C.-H.
- Affiliations
- Asia University (TW)
- Central Taiwan University of Science and Technology (TW)
- China Medical University (TW)
- Corresponding author
- Huang, Chiung-Hua
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Hindawi Limited
- Published
- 2015-02-25
- Volume
- 11
- Issue
- 3
- Pages
- 905-915
- ISSN
- 1932-6254 (ISSN-L)
- OpenAlex
- W2105698780
- Cited by
- 151
- References
- 29
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 18 · 2023: 20 · 2022: 23 · 2021: 16 · 2020: 24 · 2019: 16 · 2018: 9 · 2017: 3 · 2016: 4 · 2015: 3
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Tissue Engineering and Regenerative Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- Centella asiatica, wound healing, electrospinning, fibroblast proliferation, collagen synthesis, antibacterial activity, biodegradable membranes, hydrophilicity, skin wounds
- MeSH terms
- Animals, Anti-Bacterial Agents, Cell Count, Disease Models, Animal, Fibroblasts, Gelatin, Male, Plant Extracts, Triterpenes, Water, Wound Healing, Rats, Sprague-Dawley, Tissue Engineering, Centella, Sus scrofa, Cell Proliferation, Mice, Nanofibers
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