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Cited by 137Tissue Engineering and Regenerative MedicineBone Tissue Engineering MaterialsWound Healing and Treatments

Vascularization strategies in tissue engineering approaches for soft tissue repair

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Masson‐Meyers, Daniela Santos, Tayebi, Lobat·2021·Journal of Tissue Engineering and Regenerative Medicine
DOI 10.1002/term.3225PMC PMC8419139
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Abstract

Insufficient vascularization during tissue repair is often associated with poor clinical outcomes. This is a concern especially when patients have critical-sized injuries, where the size of the defect restricts vascularity, or even in small defects that have to be treated under special conditions, such as after radiation therapy (relevant to tumor resection) that hinders vascularity. In fact, poor vascularization is one of the major obstacles for clinical application of tissue engineering methods in soft tissue repair. As a key issue, lack of graft integration, caused by inadequate vascularization after implantation, can lead to graft failure. Moreover, poor vascularization compromises the viability of cells seeded in deep portions of scaffolds/graft materials, due to hypoxia and insufficient nutrient supply. In this article we aim to review vascularization strategies employed in tissue engineering techniques to repair soft tissues. For this purpose, we start by providing a brief overview of the main events during the physiological wound healing process in soft tissues. Then, we discuss how tissue repair can be achieved through tissue engineering, and considerations with regards to the choice of scaffold materials, culture conditions, and vascularization techniques. Next, we highlight the importance of vascularization, along with strategies and methods of prevascularization of soft tissue equivalents, particularly cell-based prevascularization. Lastly, we present a summary of commonly used in vitro methods during the vascularization of tissue-engineered soft tissue constructs.

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Cited by

Sorted by citations

Authors
Masson‐Meyers, D. S., & Tayebi, L.
Affiliations
Marquette University (US)
Corresponding author
Tayebi, Lobat
ORCID
Venue
Journal of Tissue Engineering and Regenerative Medicine
Publisher
Wiley
Published
2021-05-31
Volume
15
Issue
9
Pages
747-762
ISSN
  • 1932-6254 (ISSN-L)
  • 1932-7005
DOI
10.1002/term.3225
PMC
PMC8419139
OpenAlex
W3165520063
Cited by
137
References
0
Citations by year
2026: 28 · 2025: 44 · 2024: 26 · 2023: 24 · 2022: 14 · 2021: 1
FWCI
3.86
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Tissue Engineering and Regenerative Medicine (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Dental and Craniofacial Research
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
vascularization, soft tissue repair, tissue engineering, wound healing, graft integration, graft failure, hypoxia, scaffold materials, critical-size bone defect, radiotherapy
MeSH terms
Animals, Biocompatible Materials, Humans, Regeneration, Wound Healing, Neovascularization, Physiologic, Tissue Engineering, Regenerative Medicine

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