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In vitro cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions
Abstract
In vitro cytotoxicities were measured for ionic liquids (ILs) containing various cations and anions using the MCF7 human breast cancer cell line. We measured the cytotoxicities of ionic liquids containing the cations pyridinium, pyrrolidinium, piperidinium, or imidazolium with various alkyl chain lengths, and the anions bromide, bis(trifluoromethanesulfone)imide (Tf 2 N), trifluoromethylsulfonate (TfO), or nonafluoromethylsulfonate (NfO). Three new hydrophobic, task‐specific ionic liquids (TSILs), namely, [MBCNPip]+[Tf 2 N]−, [MPS 2 Pip]+[Tf 2 N]−, and [MPS 2 Pyrro]+[Tf 2 N]− designed for metal‐ion extraction were also evaluated. IC 50 values of the ionic liquids toward the MCF7 cells ranged from 8 μM to 44 mM. The toxicity depended significantly on the nature of the cations and anions, especially when the cations contained a long side chain. TSILs studied in this work were less toxic than the classical ILs. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
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Cited by
Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine
Egorova, K. S., Gordeev, E. G., & Ananikov, V. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00562 · Cited by 1,649
Egorova, K. S., & Ananikov, V. P. (2014) · ChemSusChem · doi:10.1002/cssc.201300459 · Cited by 441
Pirkwieser, P., López-López, J. A., Schagerl, M., Kandioller, W., Keppler, B. K., Moreno, C., & Jirsa, F. (2020) · Applied Sciences · doi:10.3390/app10093157 · Cited by 13
Metadata
- Authors
- Kumar, R. A., Papaïconomou, N., Lee, J., Salminen, J., Clark, D. S., & Prausnitz, J. M.
- Venue
- Environmental Toxicology
- Publisher
- Wiley
- Published
- 2008-09-29
- Volume
- 24
- Issue
- 4
- Pages
- 388-395
- ISSN
- 1520-4081 (ISSN-L)
- 1522-7278
- OpenAlex
- W2014522650
- Cited by
- 159
- References
- 0
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kumar, R. A., Papaïconomou, N., Lee, J., Salminen, J., Clark, D. S., & Prausnitz, J. M. (2009). In vitro cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions. Environmental Toxicology. https://doi.org/10.1002/tox.20443
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