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Cited by 24Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCognitive Abilities and Testing

Early Alzheimer's disease‐like reductions in gray matter and cognitive function with aging in nonhuman primates

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Frye, Brett M., Craft, Suzanne, Register, Thomas C., Kim, Jeongchul, Whitlow, Christopher T., Barcus, Richard A., Lockhart, Samuel N., Sai, Kiran Kumar Solingapuram +1 more·2022·Alzheimer's & Dementia: Translational Research & Clinical Interventions
DOI 10.1002/trc2.12284PMC PMC8918111
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Abstract

Introduction: Age‐related neuropathology associated with sporadic Alzheimer's disease (AD) often develops well before the onset of symptoms. Given AD's long preclinical period, translational models are needed to identify early signatures of pathological decline. Methods: Using structural magnetic resonance imaging and cognitive assessments, we examined the relationships among age, cognitive performance, and neuroanatomy in 48 vervet monkeys ( Chlorocebus aethiops sabaeus ) ranging from young adults to very old. Results: We found negative associations of age with cortical gray matter volume ( P = .003) and the temporal‐parietal cortical thickness meta‐region of interest ( P = .001). Additionally, cortical gray matter volumes predicted working memory at approximately 1‐year follow‐up (correct trials at the 20s delay [ P = .008]; correct responses after longer delays [ P = .004]). Discussion: Cortical gray matter diminishes with age in vervets in regions relevant to AD, which may increase risk of cognitive impairment. This study lays the groundwork for future investigations to test therapeutics to delay or slow pathological decline.

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  • Non-human primates can model sporadic age-associated brain β-amyloid deposition and pathological changes in AD.

    “Non-human primates (NHP) can be used as models of sporadic age-associated brain β-amyloid deposition and pathological changes in AD.”

    From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [154]

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Authors
Frye, B. M., Craft, S., Register, T. C., Kim, J., Whitlow, C. T., Barcus, R. A., Lockhart, S. N., Sai, K. K. S., & Shively, C. A.
Affiliations
Wake Forest University Health Sciences (US)
Corresponding author
Shively, Carol A.
ORCID
Venue
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Publisher
Wiley
Published
2022-01
Volume
8
Issue
1
Pages
e12284-e12284
ISSN
2352-8737 (ISSN-L)
DOI
10.1002/trc2.12284
PMC
PMC8918111
OpenAlex
W4220745787
Cited by
24
References
3
Citations by year
2026: 4 · 2025: 8 · 2024: 5 · 2023: 4 · 2022: 3
FWCI
3.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Alzheimer s & Dementia Translational Research & Clinical Interventions (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Institutes of Health (UL1TR001420, P40OD010965)
  • Wake Forest School of Medicine (UL1TR001420, T32AG033534)
  • National Institute on Aging (R24AG073199, P30AG049638, L30 AG074138, P30AG021332, T32AG033534, P30AG072947)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
Alzheimer's disease, gray matter volume, aging, vervet monkey, Chlorocebus aethiops sabaeus, nonhuman primate model, cortical thickness, working memory, cognitive decline, preclinical Alzheimer's disease, neurodegeneration

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