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Cited by 564Gynecological conditions and treatmentsReproductive System and PregnancyReproductive Health and Contraception

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Reproductive outcomes in women with congenital uterine anomalies: a systematic review

Open access
Chan, Y. Y., Jayaprakasan, K., Tan, A., Thornton, J. G., Coomarasamy, A., Raine‐Fenning, N. J.·2011·Ultrasound in Obstetrics & Gynecology
DOI 10.1002/uog.10056
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Abstract

OBJECTIVE: Congenital uterine anomalies are common but their effect on reproductive outcome is unclear. We conducted a systematic review to evaluate the association between different types of congenital uterine anomaly and various reproductive outcomes. METHODS: Searches were performed using MEDLINE, EMBASE, the Cochrane Library and Web of Science. The Newcastle-Ottawa Quality Assessment Scale was used for quality assessment. Uterine defects were grouped into arcuate uteri, canalization defects (septate and subseptate uteri) and unification defects (unicornuate, bicornuate and didelphys uteri). Pooled risk ratios (RR) with 95% confidence intervals (CI) were computed using random effects models. RESULTS: We identified nine studies comprising 3805 women. Meta-analysis showed that arcuate uteri were associated with increased rates of second-trimester miscarriage (RR, 2.39; 95% CI, 1.33-4.27, P = 0.003) and fetal malpresentation at delivery (RR, 2.53; 95% CI, 1.54-4.18; P < 0.001). Canalization defects were associated with reduced clinical pregnancy rates (RR, 0.86; 95% CI, 0.77-0.96; P = 0.009) and increased rates of first-trimester miscarriage (RR, 2.89; 95% CI; 2.02-4.14; P < 0.001), preterm birth (RR, 2.14; 95% CI, 1.48-3.11; P < 0.001) and fetal malpresentation (RR, 6.24; 95% CI, 4.05-9.62; P < 0.001). Unification defects were associated with increased rates of preterm birth (RR, 2.97; 95% CI, 2.08-4.23; P < 0.001) and fetal malpresentation (RR, 3.87; 95% CI, 2.42-6.18; P < 0.001). CONCLUSIONS: Canalization defects reduce fertility and increase rates of miscarriage and preterm delivery. None of the unification defects reduces fertility but some are associated with miscarriage and preterm delivery. Arcuate uteri are specifically associated with second-trimester miscarriage. All uterine anomalies increase the chance of fetal malpresentation at delivery.

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Research works printed but not linked: 3

  1. Tantini C, 1996, Influence of minimal septa in human gestational capacity, Ital J Gynaecol Obstet, 8, 25
  2. 2008, The Cochrane Collaboration. Review Manager (RevMan)
  3. Zupi E, 1996, Uterine anomalies prevalence and reproductive outcome in women undergoing diagnostic hysteroscopy, Gynaecol Endoscopy, 5, 147

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Metadata

Authors
Chan, Y. Y., Jayaprakasan, K., Tan, A., Thornton, J. G., Coomarasamy, A., & Raine‐Fenning, N. J.
Affiliations
  • Nottingham University Hospitals NHS Trust (GB)
  • University of Nottingham (GB)
  • Birmingham Women's Hospital (GB)
Corresponding author
Chan, Y. Y.
ORCID
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2011-09-20
Volume
38
Issue
4
Pages
371-382
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
DOI
10.1002/uog.10056
OpenAlex
W2147813481
Cited by
564
References
65
Citations by year
2026: 22 · 2025: 35 · 2024: 46 · 2023: 53 · 2022: 41 · 2021: 65 · 2020: 70 · 2019: 31 · 2018: 29 · 2017: 46 · 2016: 40 · 2015: 26 · 2014: 32 · 2013: 19 · 2012: 5
FWCI
3.25
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Ultrasound in Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
Keywords
congenital uterine anomalies, reproductive outcomes, arcuate uterus, septate uterus, subseptate uterus, unicornuate uterus, bicornuate uterus, uterus didelphys, miscarriage, preterm birth, fetal malpresentation, clinical pregnancy rate, fertility, reproductive endocrinology, infertility, pregnancy complications
MeSH terms
Abortion, Spontaneous, Female, Fertility, Humans, Labor Presentation, Pregnancy, Pregnancy Outcome, Risk Factors, Uterine Diseases, Uterus, Meta-Analysis as Topic, Premature Birth

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