Severe fetal growth restriction at 26-32 weeks: key messages from the TRUFFLE study
Open accessAbstract
What was the TRUFFLE study? The Trial of Randomized Umbilical and Fetal Flow in Europe (TRUFFLE) was a prospective, multicenter, unblinded, randomized trial that ran between 1 January 2005 and 1 October 2010 in 20 European centers 1 . It studied singleton pregnancies at 26–32 weeks of gestation with a diagnosis of fetal growth restriction (FGR), defined as abdominal circumference < 10th percentile and high umbilical artery Doppler pulsatility index (PI) (> 95th percentile). In order to assess whether changes in the fetal ductus venosus (DV) Doppler waveform or short-term variation (STV) on cardiotocography (CTG) should be used as a trigger for delivery in these pregnancies, the 503 included women were randomly allocated to one of three ‘timing-of-delivery’ plans (with 1 : 1 : 1 randomization).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In TRUFFLE, delivery decisions guided by ductus venosus Doppler findings accounted for about 11% of pregnancies allocated to the late ductus venosus findings group because most delivered due to other fetal or maternal indications.
“In TRUFFLE, delivery decisions guided by ductus venosus Doppler findings only accounted for about 11% of pregnancies allocated to the late ductus venosus findings group because most delivered due to other fetal or maternal indications.115,120,121”
From Society for Maternal-Fetal Medicine Consult Series #52: Diagnosis and management of fetal growth restriction (2020) · cites this paper as [120]
The section on deliveries for reasons other than abnormal DV Doppler (p. 4) says many women delivered for other reasons, including maternal complications and fetal distress. The section on neurological outcome (p. 4) also says that, across the two DV groups, twice as many fetuses delivered under CTG safety-net criteria as for DV changes. Neither passage gives 11% as the proportion of the late-DV group delivered because of DV findings; the reported 11% figures refer to other indications across the trial. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 8 · Cited by 96
Research works printed but not linked: 1
- [4]4. Lobmaier SM, Mensing van Charante N, Ferrazzi E, Giussani DA, Shaw CJ, M¨ uller A, Ortiz JU, Ostermayer E, Haller B, Prefumo F, Frusca T, Hecher K, Arabin B, Thilaganathan B, Papageorghiou AT, Bhide A, Martinelli P, Duvekot JJ, van Eyck J, Visser GH, Schmidt G, Ganzevoort W, Lees CC, Schneider KT; TRUFFLE investigators (see Acknowledgments). Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction - a secondary analysis of TRUFFLE-trial. Am J Obstet Gynecol 2016; 215 : 630.e1-7.
- Authors
- Bilardo, C. M., Hecher, K., Visser, G. H. A., Papageorghiou, A. T., Marlow, N., Thilaganathan, B., Van Wassenaer‐Leemhuis, A., Todros, T., Marsal, K., Frusca, T., Arabin, B., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Ganzevoort, W., Martinelli, P., Ostermayer, E., Schlembach, D., Valensise, H., Thornton, J., Wolf, H., Lees, C., & on behalf of the TRUFFLE Group
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- University Medical Center Hamburg-Eppendorf (DE)
- University Medical Center Utrecht (NL)
- St George's Hospital (GB)
- University College London (GB)
- Department of Neonatology Emma Children's Hospital Academic Medical Centre Amsterdam The Netherlands
- University of Turin (IT)
- Department of Obstetrics and Gynecology, Lund University University Hospital Lund Sweden
- University of Parma (IT)
- Philipps University of Marburg (DE)
- Innsbruck Medical University (AT)
- Wilhelmina Children's Hospital (NL)
- Erasmus MC (NL)
- University of Milan (IT)
- Amsterdam UMC Location University of Amsterdam (NL)
- Federico II University Hospital (IT)
- Technical University of Munich (DE)
- Medical University of Graz (AT)
- University of Rome Tor Vergata (IT)
- Nottingham City Hospital (GB)
- Imperial College London (GB)
- Corresponding author
- Lees, C.
- ORCID
- Venue
- Ultrasound in Obstetrics & Gynecology
- Publisher
- Wiley
- Published
- 2017-09
- Volume
- 50
- Issue
- 3
- Pages
- 285-290
- ISSN
- 0960-7692 (ISSN-L)
- 1469-0705
- OpenAlex
- W2753160328
- Semantic Scholar
- d1d1b5e5278db4a7ece3d2a62de3783f27fe9a5c
- Cited by
- 96
- References
- 8
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 14 · 2023: 10 · 2022: 9 · 2021: 15 · 2020: 11 · 2019: 9 · 2018: 5
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Ultrasound in Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- St George's Online Research Archive (St George's University of London) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, other-oa)
- Lund University Publications (Lund University) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0512-10034)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- severe fetal growth restriction, timing of delivery, short-term variability, cardiotocography, singleton pregnancy, second trimester, labor induction
- MeSH terms
- Fetal Growth Retardation, Gestational Age, Heart Rate, Fetal, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
