Cited by 109Prenatal Screening and DiagnosticsCongenital Anomalies and Fetal SurgeryFetal and Pediatric Neurological Disorders

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

The 11–13-week scan: diagnosis and outcome of holoprosencephaly, exomphalos and megacystis

Open access

Kagan, K. O., Staboulidou, I., Syngelaki, A., Cruz, J., Nicolaides, K. H.·2010·Ultrasound in Obstetrics & Gynecology

DOI 10.1002/uog.7646

Open this paper in CoChat — free account Open PDF

Abstract

OBJECTIVE: To determine the prevalence and outcome of fetuses with holoprosencephaly, exomphalos and megacystis diagnosed at 11-13 weeks of gestation. METHODS: As part of a prospective screening study for trisomy 21 in singleton pregnancies at 11 + 0 to 13 + 6 weeks' gestation, transabdominal ultrasound examination was performed to diagnose holoprosencephaly, exomphalos and megacystis. Fetal karyotype and pregnancy outcome in fetuses with these defects were examined. RESULTS: Screening was carried out in 57 119 pregnancies. The prevalence of holoprosencephaly, exomphalos and megacystis was 1 : 1298, 1 : 381 and 1 : 1632, respectively. Chromosomal abnormalities, mainly trisomies 18 and 13, were found in 65.9% of fetuses with holoprosencephaly, in 55.3% with exomphalos and in 31.4% with megacystis. There was spontaneous resolution of the defect by 20 weeks in 92.5% of euploid fetuses with exomphalos containing only bowel and in 90% of the euploid fetuses with megacystis and bladder length of < or = 15 mm. CONCLUSIONS: A high proportion of fetuses with holoprosencephaly, exomphalos and megacystis diagnosed at 11-13 weeks of gestation are aneuploid, but in the majority of cases exomphalos and megacystis represent temporary abnormalities that resolve spontaneously.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/uog.7646

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10–14 weeks of gestation
Snijders, R., Noble, P., Sebire, N., Souka, A., & Nicolaides, K. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11280-6 · Cited by 1,572
Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha‐fetoprotein level
Cuckle, H., Wald, N., & THOMPSON, S. G. (1987) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1987.tb03115.x · Cited by 607
Multicenter study of first‐trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk‐orientated two‐stage first‐trimester screening
Nicolaides, K. H., Spencer, K., Avgidou, K., Faiola, S., & Falcón, O. (2005) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.1860 · Cited by 450
Holoprosencephaly
Dubourg, C., Bendavid, C., Pasquier, L., Henry, C., Odent, S., & David, V. (2007) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-2-8 · Cited by 355
Natural history of trisomy 18 and trisomy 13: I. Growth, physical assessment, medical histories, survival, and recurrence risk
Baty, B. J., Blackburn, B. L., & Carey, J. C. (1994) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320490204 · Cited by 346
Holoprosencephaly in human embryos: Epidemiologic studies of 150 cases
Matsunaga, E., & Shiota, K. (1977) · Teratology · doi:10.1002/tera.1420160304 · Cited by 329
Maternal Age and Gestational Age-Specific Risk for Chromosomal Defects
Snijders, R. J. M., Sebire, N. J., & Nicolaides, K. H. (2009) · Fetal Diagnosis and Therapy · doi:10.1159/000264259 · Cited by 278
Screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free -hCG and pregnancy-associated plasma protein-A
Kagan, K. O., Wright, D., Valencia, C. M. M., Maíz, N., & Nicolaides, K. H. (2008) · Human Reproduction · doi:10.1093/humrep/den224 · Cited by 263
Megacystis at 10–14 weeks of gestation: Chromosomal defects and outcome according to bladder length
Liao, A. W., Sebire, N. J., Geerts, L., Cicero, S., & Nicolaides, K. H. (2003) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.81 · Cited by 193
Self-citation
Fetal megacystis at 10–14 weeks of gestation
Sebire, N. J., Kaisenberg, C. V., Rubio, C., Snijders, R. J. M., & Nicolaides, K. H. (1996) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1997.08060387.x · Cited by 159

Show all 19 references

Sorted by citations

Screening for fetal aneuploidies at 11 to 13 weeks
Nicolaides, K. H. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2637 · Cited by 644
Challenges in the diagnosis of fetal non‐chromosomal abnormalities at 11–13 weeks
Syngelaki, A., Chelemen, T., Dagklis, T., Allan, L. D., & Nicolaides, K. H. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2642 · Cited by 497
Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224
Holoprosencephaly: A Survey of the Entity, with Embryology and Fetal Imaging
Winter, T. C., Kennedy, A., & Woodward, P. J. (2015) · Radiographics · doi:10.1148/rg.351140040 · Cited by 137
Effectiveness of vesicoamniotic shunt in fetuses with congenital lower urinary tract obstruction: an updated systematic review and meta‐analysis
Nassr, A. A., Shazly, S. A., Abdelmagied, A. M., Júnior, E. A., Tonni, G., Kilby, M. D., & Ruano, R. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15988 · Cited by 133
Trisomy 13 detection in the first trimester of pregnancy using a chromosome‐selective cell‐free DNA analysis method
Ashoor, G., Syngelaki, A., Wang, E., Struble, C. A., Oliphant, A., Song, K., & Nicolaides, K. H. (2012) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.12299 · Cited by 115
Fetal abdominal wall defects
Prefumo, F., & Izzi, C. (2013) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.10.003 · Cited by 114
First‐trimester detection of structural abnormalities and the role of aneuploidy markers
Grande, M., Arigita, M., Borobio, V., Jimenez, J. M., Fernández, S. G., & BORRELL, A. (2011) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.10070 · Cited by 110
Fetal megacystis: A systematic review
Taghavi, K., Sharpe, C., & Stringer, M. D. (2016) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2016.09.003 · Cited by 86
Syndromes associated with holoprosencephaly
Kruszka, P. S., & Muenke, M. (2018) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31620 · Cited by 76
Chances and Challenges of New Genetic Screening Technologies (NIPT) in Prenatal Medicine from a Clinical Perspective: A Narrative Review
Bedei, I. A., Wolter, A., Weber, A., Signore, F., & Axt-Fliedner, R. (2021) · Genes · doi:10.3390/genes12040501 · Cited by 84
First-trimester screening for trisomies 18 and 13, triploidy and Turner syndrome by detailed early anomaly scan
Wagner, P., Sonek, J., Hoopmann, M., Abele, H., & Kagan, K. O. (2016) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.15829 · Cited by 68
Self-citation
Sonographic detection of central nervous system defects in the first trimester of pregnancy
Engels, A., Joyeux, L., Brantner, C., Keersmaecker, B. D., Catte, L. D., Baud, D., Deprest, J. A., & Mieghem, T. V. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4770 · Cited by 62
Impact of holoprosencephaly, exomphalos, megacystis and increased nuchal translucency on first‐trimester screening for chromosomal abnormalities
Syngelaki, A., Guerra, L., Ceccacci, I., Efetürk, T., & Nicolaides, K. H. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.17286 · Cited by 56
Diagnosis of Fetal Structural Anomalies at 11 to 14 Weeks
Vayna, A. M., Veduță, A., Duţă, S., Panaitescu, A. M., Stoica, S., Buinoiu, N. F., Nedelea, F. M., & Peltecu, G. C. (2018) · Journal of Ultrasound in Medicine · doi:10.1002/jum.14561 · Cited by 54
First trimester screening for holoprosencephaly with choroid plexus morphology (‘butterfly’ sign) and biparietal diameter
Sepulveda, W., & Wong, A. E. (2013) · Prenatal Diagnosis · doi:10.1002/pd.4235 · Cited by 49
Outcome of fetal exomphalos diagnosed at 11–14 weeks of gestation
Khalil, A. A., Arnaoutoglou, C., Pacilli, M., Szabó, A., David, A. L., & Pandya, P. P. (2011) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.10048 · Cited by 49
Omphalocele in the first trimester: prediction of perinatal outcome
Tassin, M., Descriaud, C., Elie, C., Debarge, V., Dumez, Y., Perrotin, F., & Benachi, A. (2013) · Prenatal Diagnosis · doi:10.1002/pd.4102 · Cited by 49
First Trimester Noninvasive Prenatal Diagnosis: A Computational Intelligence Approach
Neocleous, A. C., Nicolaides, K. H., & Schizas, C. N. (2015) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2015.2462744 · Cited by 35
AIUM Practice Parameter for the Performance of Detailed Diagnostic Obstetric Ultrasound Examinations Between 12 Weeks 0 Days and 13 Weeks 6 Days
(2020) · Journal of Ultrasound in Medicine · doi:10.1002/jum.15477 · Cited by 38
Current state of MRI of the fetal brain in utero
Jarvis, D. A., & Griffiths, P. D. (2018) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26316 · Cited by 33
Molecular testing in holoprosencephaly
Kruszka, P. S., Martinez, A. F., & Muenke, M. (2018) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31617 · Cited by 32
Congenital urinary tract obstruction
Cheung, K. W., Morris, R. K., & Kilby, M. D. (2019) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2019.01.003 · Cited by 31
Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy
Fontanella, F., Duin, L. K., van Scheltema, P. N. A., Cohen‐Overbeek, T. E., Pajkrt, E., Bekker, M. N., Willekes, C., Bax, C. J., Oepkes, D., & Bilardo, C. M. (2018) · Fetal Diagnosis and Therapy · doi:10.1159/000488282 · Cited by 24
Combined First Trimester Screening and Cell-Free Fetal DNA – “Next Generation Screening”
Kagan, K. O., Eiben, B., & Kozlowski, P. (2014) · Ultraschall in der Medizin - European Journal of Ultrasound · doi:10.1055/s-0034-1366353 · Cited by 23
Outcomes in fetuses diagnosed with megacystis: Systematic review and meta-analysis
Chen, L., Guan, J., Gu, H., & Zhang, M. (2018) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2018.12.007 · Cited by 24
Single-center outcome analysis of 46 fetuses with megacystis after intrauterine vesico-amniotic shunting with the Somatex®intrauterine shunt
Gottschalk, I., Berg, C., Menzel, T., Abel, J. S., Kribs, A., Dübbers, M., Kohaut, J., Weber, L. T., Taylan, C., Habbig, S., et al. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06905-6 · Cited by 24
Diagnosis of abdominal wall defects in the first trimester
Tassin, M., & Benachi, A. (2014) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000053 · Cited by 23
Practice guidelines of the Polish Society of Gynecologists and Obstetricians - Ultrasound Section for ultrasound screening in uncomplicated pregnancy - 2020
Borowski, D., Pietryga, M., Basta, P., Cnota, W., Czuba, B., Dubiel, M., Fuchs, T., Huras, H. K., Iciek, R., Jaczyńska, R., et al. (2020) · Ginekologia Polska · doi:10.5603/gp.2020.0110 · Cited by 23
Intrauterine vesicoamniotic shunting for fetal megacystis
Stadié, R., Strizek, B., Gottschalk, I., Geipel, A., Gembruch, U., & Berg, C. (2016) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-016-4152-4 · Cited by 21
Prenatal diagnosis and pregnancy outcome of major structural anomalies detectable in the first trimester: A population‐based cohort study in the Netherlands
Bardi, F., Bergman, J. E. H., Siemensma‐Mühlenberg, N., Elvan‐Taşpınar, A., de Walle, H. E. K., & Bakker, M. K. (2022) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12914 · Cited by 20
First Trimester Ultrasound Detection of Fetal Central Nervous System Anomalies
Ungureanu, D. R., Drăgușin, R. C., Căpitănescu, R. G., Zorilă, L., Ofițeru, A. M. I., Marinaș, C., Pătru, C. L., Comănescu, A. C., Comănescu, M. C., Sîrbu, O. C., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13010118 · Cited by 20
Megacystis in the first trimester of pregnancy: Prognostic factors and perinatal outcomes
Lesieur, E., Barrois, M., Bourdon, M., Blanc, J., Lœuillet, L., Delteil, C., Torrents, J., Bretelle, F., Grangé, G., Tsatsaris, V., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255890 · Cited by 17
Evaluation of First-Trimester Physiological Midgut Herniation Using Three-Dimensional Ultrasound
Bogers, H., Baken, L., Cohen-Overbeek, T. E., Koning, A. H. J., Willemsen, S. P., van der Spek, P. J., Exalto, N., & Steegers, E. A. P. (2019) · Fetal Diagnosis and Therapy · doi:10.1159/000489260 · Cited by 17
Early fetal anatomical sonography
Donnelly, J. C., & Malone, F. D. (2012) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2012.06.002 · Cited by 16
The effect of the contents of exomphalos and nuchal translucency at 11–14 weeks on the likelihood of associated chromosomal abnormality
Iacovella, C., Contro, E., Ghi, T., Pilu, G., Papageorghiou, A. T., Thilaganathan, B., & Bhide, A. (2012) · Prenatal Diagnosis · doi:10.1002/pd.3959 · Cited by 15
The wide spectrum of ultrasound diagnosis of holoprosencephaly
Ionescu, C. A., Vlădăreanu, S., Tudorache, Ş., Pleș, L., Herghelegiu, C. G., Neacşu, A., Navolan, D. B., Drăgan, I., & Oprescu, D. (2019) · Medical Ultrasonography · doi:10.11152/mu-1614 · Cited by 11
First Trimester Ultrasound Assessment for Fetal Aneuploidy
Hyett, J. A., Mogra, R., & Sonek, J. (2014) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000013 · Cited by 11
Biparietal Diameter–to–Crown‐Rump Length Disproportion in First‐Trimester Fetuses With Holoprosencephaly
Sepúlveda, W., Wong, A. E., En, A., Odegova, N., Martínez-Ten, P., & Meagher, S. E. (2014) · Journal of Ultrasound in Medicine · doi:10.7863/ultra.33.7.1165 · Cited by 11
First trimester fetal anatomy study and identification of major anomalies using 10 standardized scans
Colosi, E. (2015) · Journal of Prenatal Medicine · doi:10.11138/jpm/2015.9.3.024 · Cited by 10
Postnatal Management in Congenital Lower Urinary Tract Obstruction With and Without Prenatal Vesicoamniotic Shunt
Jank, M., Stein, R., & Younsi, N. F. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.635950 · Cited by 11
Patterning of the antero‐ventral mammalian brain: Lessons from holoprosencephaly comparative biology in man and mouse
Barratt, K. S., Drover, K. A., Thomas, Z. M., & Arkell, R. M. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1552 · Cited by 10
Nichtinvasive Pränataldiagnostik
Eiben, B., Glaubitz, R., & Kagan, K. O. (2014) · Medizinische Genetik · doi:10.1007/s11825-014-0021-3 · Cited by 10
Prenatal ultrasound findings of holoprosencephaly spectrum: Unusual associations
El‐Dessouky, S. H., Aboulghar, M. M., Gaafar, H. M., Abdella, R., Sharaf, M. F., Ateya, M. I., Elarab, A. E., Zidan, W. H., Helal, R. M., Aboelsaud, S. M., et al. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5649 · Cited by 9
Combined screening test for trisomy 21 – is it as efficient as we believe?
Wiechec, M. T., Nocuń, A., Knafel, A., Wiercińska, E., Sonek, J., Rozmus-Warcholińska, W., Orzechowski, M., Stettner, D., & Plevak, P. (2016) · Journal of Perinatal Medicine · doi:10.1515/jpm-2016-0031 · Cited by 9
Turner syndrome-omphalocele association: incidence, karyotype, phenotype and fetal outcome
Bedei, I., Gloning, K., Joyeux, L., Meyer‐Wittkopf, M., Willner, D., Krapp, M., Scharf, A., Degenhardt, J., Heling, K., Kozlowski, P., et al. (2023) · Prenatal Diagnosis · doi:10.1002/pd.6302 · Cited by 8
Prenatal diagnosis of exomphalos and prediction of outcome
Nitzsche, K., Fitze, G., Rüdiger, M., Wimberger, P., & Birdir, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-88245-0 · Cited by 8
Combined First Trimester Screening and Cell-Free Fetal DNA -" Next Generation Screening" Kombiniertes Ersttrimesterscreening und zellfreie fetale DNA -" Next Generation Screening"
Kagan, K. O., Eiben, B., & Kozlowski, P. (2014) · Cited by 7
Assessment of fetal malformations in the first trimester of pregnancy by three-dimensional ultrasonography in the rendering mode. Pictorial essay.
Júnior, E. A., Rôlo, L. C., Tonni, G., Haeri, S., & Ruano, R. (2015) · Medical Ultrasonography · doi:10.11152/mu.2013.2066.171.eaj · Cited by 7
Non‐Invasive Prenatal Testing by Cell‐Free DNA ( cfNIPT ) for Detecting Turner Syndrome With Mosaicism and Structural Variants—Prenatal Findings and Postnatal Outcomes
Bedei, I. A., Bruder, J., Lund, I. C. B., Thomsen, S. H., Vogel, I., Maciel‐Guerra, A. T., Álvarez‐Nava, F., Crenshaw, M., Axt-Fliedner, R., Gravholt, C. H., et al. (2025) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.32136 · Cited by 7
Fetal Omphalocele: Review of Predictive Factors Important for Antenatal Counseling?
Rieder, W., Maurer, S. V., Giannoni, É., & Baud, D. (2022) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000001073 · Cited by 6
Holoprosencephaly
Blaas, H.-G. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44548-1.00039-5 · Cited by 6
A very rare entity of diabetes insipidus associated with Edwards Syndrome
Demir, N., Doğan, M., Peker, E., Bala, K. A., & Tuncer, O. (2013) · Genetics Research · doi:10.1017/s0016672313000165 · Cited by 6
Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: A mixed-methods study
Karim, J. N., Campbell, H., Pandya, P., Wilson, E. C. F., Alfirevic, Z., Chudleigh, T., Duff, E., Fisher, J., Goodman, H., Hinton, L., et al. (2025) · Health Technology Assessment · doi:10.3310/nltp7102 · Cited by 5
Fetal Anatomic Imaging Between 11 and 14 Weeks Gestation
Liff, I., & Bromley, B. (2017) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000296 · Cited by 5
Biparietal diameter at 11 to 13 weeks' gestation in fetuses with holoprosencephaly
Khalil, A. A., Papageorghiou, A. T., Bhide, A., Akolekar, R., & Thilaganathan, B. (2013) · Prenatal Diagnosis · doi:10.1002/pd.4269 · Cited by 6
Bladder outlet obstruction
Mardy, A. H. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.06.039 · Cited by 6
Fetal Central Nervous System
Alford, R. E., Bailey, A. A., & Twickler, D. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-21428-3_6 · Cited by 5
Early diagnosis and intervention in congenital lower urinary tract obstruction: time to revise our approach?
Mulder, J., Kohl, S., Fontanella, F., Hilger, A. C., Reutter, H. M., Stein, R., Weber, E. C., & Westland, R. (2025) · Pediatric Nephrology · doi:10.1007/s00467-025-06994-w · Cited by 5
Basic sonographic examination of the fetal brain at 11–13 weeks' gestation: Rationale for a simple and reliable four‐step technique
Sepúlveda, W., Garcia‐Rodriguez, R., Martínez-Ten, P., Tonni, G., Grisolia, G., & Meagher, S. E. (2023) · Journal of Clinical Ultrasound · doi:10.1002/jcu.23337 · Cited by 4
2014 First-trimester ultrasound forum from the Korean Society of Ultrasound in Obstetrics and Gynecology
Oh, S., Hong, J. S., Seol, H., Hwang, H. S., Park, H. S., Kim, K., Ko, H. S., Kwak, D.-W., Kim, M. Y., Park, M. H., et al. (2015) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2015.58.1.1 · Cited by 4
Ultrasound and magnetic resonance imaging features of fetal urogenital anomalies: A pictorial essay
Moradi, B., Golezar, M. H., Ardestani, R. M., Hassanzadeh, S., Jannatdoust, P., Banihashemian, M., & Batavani, N. (2024) · Congenital Anomalies · doi:10.1111/cga.12568 · Cited by 3
Prenatal Screening for Chromosomal Defects
Frisová, V. (2025) · Reproductive Medicine · doi:10.3390/reprodmed6020015 · Cited by 3
First-Trimester Detection of Fetal Anomalies
Napolitano, R., & Papageorghiou, A. T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-7020-4591-2.00001-2 · Cited by 2
The First-Trimester Fetal Head and Brain
Monteagudo, A., & Timor‐Tritsch, I. E. (2023) · Springer eBooks · doi:10.1007/978-3-031-24133-8_19 · Cited by 2
Imaging of the Fetus and the Uteroplacental Blood Supply: Ultrasound
Nicolaides, K. H. (2012) · Wiley eBooks · doi:10.1002/9781118477076.ch9 · Cited by 2
Are the prevalence of Trisomy 13 and the incidence of severe holoprosencephaly increasing in Africa?
Okoye, J. O., & Ngokere, A. A. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5777 · Cited by 2
Fetal Megacystis in an Asymptomatic Patient With an Intact Tubal Pregnancy at 11 Weeks' Gestation
Sammour, R. N., Mattar, E., Arad, A., Egenburg, S., & Leibovitz, Z. (2012) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2012.31.8.1292 · Cited by 1
Outcome of prenatally diagnosed central nervous system malformations in a tertiary center in Singapore
Geetha, O., Chandran, S., Sriram, B., Yeo, S. H., Gomez, D. J. M., & Rajadurai, V. S. (2016) · Pediatric Review International Journal of Pediatric Research · doi:10.17511/ijpr.2016.i08.03 · Cited by 1
The Fetal Brain in Fetuses with Orofacial Abnormalities
Malinger, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-32516-3_9 · Cited by 1
Ultrasound Screening for Fetal Abnormalities in the First Trimester
Bilardo, C. M., & Ushakov, F. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-7020-6956-7.00019-1 · Cited by 1
Assessment of the maxilla‐mandible‐nasion angle in normal and aneuploid foetuses in the first trimester of pregnancy
TEKESIN, I., & Graupner, O. (2020) · Journal of Clinical Ultrasound · doi:10.1002/jcu.22955 · Cited by 1
Fetal Anomalies
Monteagudo, A., Dziadosz, M., & Timor‐Tritsch, I. E. (2015) · Springer eBooks · doi:10.1007/978-3-319-20203-7_19 · Cited by 1
Screening for early fetal structural anomalies
Dias, T. (2012) · Sri Lanka Journal of Obstetrics and Gynaecology · doi:10.4038/sljog.v33i4.4810 · Cited by 1
First-Trimester Ultrasound: A Comparative Review of Guidelines
Boureka, E., Tsakiridis, I., Michos, G., Liberis, A., Giouleka, S., Mamopoulos, A., Kalogiannidis, I., & Dagklis, T. (2026) · Diagnostics · doi:10.3390/diagnostics16111695
Ultrasound of the Fetus During the First Trimester
Massoud, M., Massardier, J., & Guibaud, L. (2013) · Springer eBooks · doi:10.1007/978-3-642-13327-5_127
Visualización de la anatomía fetal por ecografía prenatal entre las semanas 11-13+6
Gámez, M. R., Grant, G., Azumendi, G., Cantarero, J. G. G., & Borenstein, M. (2011) · Diagnóstico Prenatal · doi:10.1016/j.diapre.2010.01.006
Prenatal diagnosis of omphalopagus conjoined twins with shared megacystis
Bravo, C., Sanjuan, C., Gámez, F., Pérez, R., & León-Luis, J. A. D. (2013) · Journal of Clinical Ultrasound · doi:10.1002/jcu.22113
Prenatal Diagnosis or Urological Abnormalities
Pilu, G. (2014) · Springer eBooks · doi:10.1007/978-88-470-5693-0_1
Outcome of fetal exomphalos diagnosed at 11–14weeks of gestation
Fanaroff, A. A. (2012) · Yearbook of Neonatal and Perinatal Medicine · doi:10.1016/j.ynpm.2012.06.002
Normal First Trimester of Pregnancy
Hack, K., & Glanc, P. (2015) · Springer eBooks · doi:10.1007/978-3-319-20203-7_7
Der nichtinvasive Pränataltest (NIPT) sinnvoll eingesetzt
Krapp, M. (2016) · Der Gynäkologe · doi:10.1007/s00129-016-3886-1
Can a temporary isolated fetal megacystis during first trimester result in unexplained intrauterine fetal death at third trimester?: a case report and review of the literature
Hacıvelioğlu, S. (2012) · Perinatal Journal · doi:10.2399/prn.12.0202006
Commentary to “Fetal megacystis: A systematic review”
Beckers, G. M. A. (2016) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2016.10.013
Mikrozephalie im zweiten Trimenon
Distler, W., Pränatalmedizin, B., & Tübingen, U. (2012)
SHORT PAPER A very rare entity of diabetes insipidus associated with Edwards Syndrome
Demir, N., Peker, E., Bulan, K., & Tuncer, U. D. M. (2013)
Fehlbildungen: Erkennbarkeit im 1. Trimenon
Siegmann, H. J. (2017) · Frauenheilkunde up2date · doi:10.1055/s-0043-105915
Typical changes of ethmocephaly and holoprosencephaly in a fetus at 14 weeks of gestation
Altmann, R., Allerstorfer, C., Scharnreitner, I., & Arzt, W. (2019) · Case Reports in Perinatal Medicine · doi:10.1515/crpm-2018-0042
Lower Urinary Tract Obstruction: Pathophysiology, Prenatal Assessment, andIn UteroIntervention
Cheung, K. W., Morris, R. K., & Kilby, M. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108564434.042
Prenatal Diagnosis of Fetal Malformations by Ultrasound
van Leeuwen, E., Lugthart, M. A., & Pajkrt, E. (2021) · Wiley eBooks · doi:10.1002/9781119676980.ch17
Clinical Use of 3D Sonography
Kurjak, A., & Barišić, L. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-83434-0_13
Current awareness in prenatal diagnosis
(2010) · Prenatal Diagnosis · doi:10.1002/pd.2363
Ersttrimesterultraschall
Hoopmann, M., & Kagan, K. O. (2017) · Springer eBooks · doi:10.1007/978-3-662-53662-9_4
Sintelencefalia en una recién nacida
Villarreal-Garza, E., & García-Espinosa, P. G. (2021) · Revista Mexicana de Pediatría · doi:10.35366/103902
Ersttrimesterscreening
Kagan, K. O., Abele, H., & Hoopmann, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-29633-8_5
Ersttrimesterscreening
Kagan, K. O., Abele, H., & Hoopmann, M. (2017) · Springer eBooks · doi:10.1007/978-3-662-53662-9_5
Erstes Trimenon
Kagan, K. O., & Hoopmann, M. (2020) · Elsevier eBooks · doi:10.1016/b978-3-437-21901-6.00001-4
Ersttrimesterultraschall
Hoopmann, M., & Kagan, K. O. (2013) · Springer eBooks · doi:10.1007/978-3-642-29633-8_4
Genetics meets ultrasound
Bardi, F. (2022) · doi:10.33612/diss.245084236
Normal First Trimester of Pregnancy
Hack, K., & Glanc, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-24133-8_8

Authors: Kagan, K. O., Staboulidou, I., Syngelaki, A., Cruz, J., & Nicolaides, K. H.
Affiliations: Harris Birthright Research Centre for Fetal Medicine (GB)
University College Hospital (GB)
Corresponding author: Nicolaides, K. H.
ORCID: Kagan, K. O.
Staboulidou, I.
Syngelaki, A.
Cruz, J.
Nicolaides, K. H.
Venue: Ultrasound in Obstetrics & Gynecology
Publisher: Wiley
Published: 2010-06-24
Volume: 36
Issue: 1
Pages: 10-14
ISSN: 0960-7692 (ISSN-L)
1469-0705
DOI: 10.1002/uog.7646
OpenAlex: W1977475819
Cited by: 108
References: 19
Citations by year: 2026: 2 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 4 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 10 · 2012: 10
FWCI: 7.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Ultrasound in Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Fetal Medicine Foundation (1 037 116)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
Health Sciences › Medicine › Surgery › Congenital Anomalies and Fetal Surgery
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords: holoprosencephaly, omphalocele, megacystis, first-trimester ultrasound screening, Down syndrome, fetal aneuploidy, trisomy 18, trisomy 13, spontaneous resolution, fetal karyotype, pregnancy outcomes, prevalence
MeSH terms: Adolescent, Adult, Urinary Bladder, Down Syndrome, Female, Gestational Age, Hernia, Umbilical, Humans, Middle Aged, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Remission, Spontaneous, Prevalence, Holoprosencephaly, Ultrasonography, Prenatal, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The 11–13-week scan: diagnosis and outcome of holoprosencephaly, exomphalos and megacystis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks