Psychotic experiences and their significance
Open accessAbstract
Certainly, the evidence based on family studies suggests that subclinical psychotic experiences are influenced by genetic risk factors.In theory this may offer a unique prospect to develop a screening test based on genetic composition.Indeed, similarly to the asserted nature of the extended psychosis phenotype, the genetic risk for psychosis is distributed on a continuum at the highest end of which are affected individuals followed by their healthy relatives 11 .Although these results support the premise of being able to detect those at risk based on their genetic make-up, recent attempts of linking genetic risk score for schizophrenia to an intermediate phenotype in non-clinical populations have so far been contradictory 12 .The importance of the transdiagnostic and extended psychosis phenotype in relation to diagnosis, aetiology, prevalence and outlining the future direction for research is indeed noteworthy.However, without a clearly established and scientifically validated threshold defining pathology, as well as markers indicative of susceptibility to the illness, the borderline between normality and psychopathology will remain contested.
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Delusional ideation represents multifactorial and dynamic rather than all-or-nothing or static phenomena.
“Recent theories suggest that different kinds of delusional ideation are located on a continuum between mild and severe (Betts et al., 2018) and represent multifactorial (Yung and Lin, 2016) and dynamic rather than all-or-nothing or static phenomena.”
From “I was trying to save the world”: delusion-like ideation and associated impacts reported by Western practitioners of Buddhist meditation (2025) · cites this paper as Yung and Lin, 2016
Our results support the notion that subtypes of PLE might differentially be implicated in mental health and well-being.
“At the same time, our results support the notion that subtypes of PLE might differentially be implicated in mental health and well-being (Yung and Lin, 2016).”
From Psychotic-Like Experiences at the Healthy End of the Psychosis Continuum (2017) · cites this paper as Yung and Lin, 2016
Psychotic experiences are mostly transitory sub-threshold manifestations that are not to be conflated with clinical psychotic symptoms, but could represent a potential surrogate biomarker of psychosis (risk of psychosis: 0.5-1% per year).
“These mostly transitory sub-threshold manifestations are not to be conflated with clinical psychotic symptoms (see below) 162 , but could represent a potential surrogate biomarker of psychosis (risk of psychosis: 0.5-1% per year 160 )”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [162]
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References 11 · Cited by 37
Research works printed but not linked: 22
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- Kelleher I, Clarke MC, Rawdon C et al. Schiz- ophr Bull 2013;39:1018-26. DOI:10.1002/wps.20328 High time for a paradigm shift in psychiatry There is no doubt that several people, especially during their childhood and adolescence, have some sort of psychotic- like experiences, and that only a minority of them go on to develop a serious psychi- atric disease. We completely agree on this
- Authors
- Yung, A. R., & Lin, A.
- Affiliations
- University of Manchester (GB)
- The Kids Research Institute Australia (AU)
- Venue
- World Psychiatry
- Publisher
- Wiley
- Published
- 2016-06
- Volume
- 15
- Issue
- 2
- Pages
- 130-131
- ISSN
- 1723-8617 (ISSN-L)
- 2051-5545
- PMC
- PMC4911755
- OpenAlex
- W2414316987
- Cited by
- 37
- References
- 11
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- World Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- subclinical psychotic experiences, genetic risk factors, endophenotypes, schizophrenia, polygenic risk score, psychosis screening, transdiagnostic features
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