Cited by 726Mitochondrial Function and PathologyNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

Poderoso, Juan José, Carreras, Marı́a Cecilia, Lisdero, Constanza, Riobó, Natalia, Schöpfer, Francisco, Boveris, Alberto·1996·Archives of Biochemistry and Biophysics

DOI 10.1006/abbi.1996.0146

Open this paper in CoChat — free account

Abstract

Nitric oxide (.NO) released by S-nitrosoglutathione (GSNO) inhibited enzymatic activities of rat heart mitochondrial membranes. Cytochrome oxidase activity was inhibited to one-half at an effective .NO concentration of 0.1 microM, while succinate- and NADH-cytochrome-c reductase activities were half-maximally inhibited at 0.3 microM .NO. Submitochondrial particles treated with .NO (either from GSNO or from a pure solution) showed increased O(-)(2) and H202 production when supplemented with succinate alone, at rates that were comparable to those of control particles with added succinate and antimycin. Rat heart mitochondria treated with .NO also showed increased H2O2 production. Cytochrome spectra and decreased enzymatic activities in the presence of .NO are consistent with a multiple inhibition of mitochondrial electron transfer at cytochrome oxidase and at the ubiquinone-cytochrome b region of the respiratory chain, the latter leading to the increased O2- production. Electrochemical detection showed that the buildup of a .NO concentration from GSNO was interrupted by submitochondrial particles supplemented with succinate and antimycin and was restored by addition of superoxide dismutase. The inhibitory effect of .NO on cytochrome oxidase was also prevented under the same conditions. Apparently, mitochondrial O2- reacts with .NO to form peroxynitrate and, by removing .NO, reactivates the previously inhibited cytochrome oxidase. It is suggested that, at physiological concentrations of .NO, inhibition of electron transfer, .NO-induced O2- production, and ONOO- formation participate in the regulatory control of mitochondrial oxygen uptake.

Integrity signals

Registry

Crossref · 10.1006/abbi.1996.0146

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Free Radicals in Biology
Pryor, W. A. (1976) · Cited by 1,876

Flagged first, then by citations

Show all 1 references

Sorted by citations

Items 101–200 of 724

CO–metal interaction: vital signaling from a lethal gas
Boczkowski, J., Poderoso, J. J., & Motterlini, R. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.09.001 · Cited by 185
Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia
Boczkowski, J., Lisdero, C. L., Lanone, S., Samb, A., Carreras, M. C., Boveris, A., Aubier, M., & Poderoso, J. J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1637 · Cited by 179
Peroxynitrite
Murphy, M. P., Packer, M. A., Scarlett, J. L., & Martin, S. W. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)00418-7 · Cited by 180
Nitric Oxide, Mitochondria, and Cell Death
Brown, G. C., & Borutaitė, V. (2001) · IUBMB Life · doi:10.1080/15216540152845993 · Cited by 185
Redox regulation of mitochondrial biogenesis
Piantadosi, C. A., & Suliman, H. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.014 · Cited by 183
HO‐1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism
Converso, D. P., Taillé, C., Carreras, M. C., Jaitovich, A., Poderoso, J. J., & Boczkowski, J. (2006) · The FASEB Journal · doi:10.1096/fj.05-4204fje · Cited by 177
Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66Shc and monoamine oxidase
Lisa, F. D., Kaludercic, N., Carpi, A., Menabò, R., & Giorgio, M. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0008-4 · Cited by 176
Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle
Marzetti, E., Wohlgemuth, S. E., Lees, H. A., Chung, H.-Y., Giovannini, S., & Leeuwenburgh, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.05.005 · Cited by 172
Nitric oxide and mitochondria
Guy, C. B. (2006) · Frontiers in bioscience · doi:10.2741/2122 · Cited by 172
Mitochondria as a Target for the Cardioprotective Effects of Nitric Oxide in Ischemia–Reperfusion Injury
Burwell, L. S., & Brookes, P. S. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1845 · Cited by 177
Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease
Carreras, M. C. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.014 · Cited by 167
The role of mitochondrial nitric oxide synthase in inflammation and septic shock
Boveris, A., Álvarez, S., & Navarro, A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01009-2 · Cited by 167
Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-κB and inhibition of Bcl-xL expression
Huerta‐Yépez, S., Vega, M. I., Jazirehi, A. R., Garbán, H., Hongo, F., Cheng, G., & Bonavida, B. (2004) · Oncogene · doi:10.1038/sj.onc.1207655 · Cited by 166
Role of Endothelium-Derived Nitric Oxide in the Regulation of Cardiac Oxygen Metabolism
Trochu, J., Bouhour, J.-B., Kaley, G., & Hintze, T. H. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1108 · Cited by 163
Hydrogen sulphide: novel opportunity for drug discovery
Martelli, A., Testai, L., Breschi, M. C., Blandizzi, C., Virdis, A., Taddei, S., & Calderone, V. (2010) · Medicinal Research Reviews · doi:10.1002/med.20234 · Cited by 161
Sites and Mechanisms of Aconitase Inactivation by Peroxynitrite: Modulation by Citrate and Glutathione
Han, D., Canali, R., Garcia, J., Aguilera, R., Gallaher, T. K., & Cadenas, E. (2005) · Biochemistry · doi:10.1021/bi0509393 · Cited by 161
Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system
Peuchen, S., Bolaños, J. P., Heales, S., Almeida, Á., Duchen, M. R., & Clark, J. B. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00010-5 · Cited by 160
Minireview: The Quantitative Measurement of H2O2 Generation in Isolated Mitochondria
Barja, G. (2002) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1016039604958 · Cited by 158
The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance
Poderoso, J. J., Carreras, M. C., Schopfer, F. J., Lisdero, C. L., Galdo, N. A. R., Giulivi, C., Boveris, A. D., Boveris, A., & Cadenas, E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00277-9 · Cited by 156
Systemic and mitochondrial adaptive responses to moderate exercise in rodents
Boveris, A., & Navarro, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.015 · Cited by 154
Long-term antipsychotic treatments and crossover studies in rats: Differential effects of typical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brain
Pillai, A., Parikh, V., Terry, A. V., & Mahadik, S. P. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.011 · Cited by 153
Melatonin counteracts inducible mitochondrial nitric oxide synthase‐dependent mitochondrial dysfunction in skeletal muscle of septic mice
Escames, G., López, L. C., Tapias, V., Utrilla, P., Reiter, R., Hitos, A. B., León, J., Rodríguez, M. I., & Acuña-Castroviejo, D. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00281.x · Cited by 158
A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress
LeBaron, T. W., Kura, B., Kaločayová, B., Tribulová, N., & Slezák, J. (2019) · Molecules · doi:10.3390/molecules24112076 · Cited by 151
Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice
Escames, G., López, L. C., Ortiz, F., López, A., García, J. A. G., Ros, E., & Acuña-Castroviejo, D. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05755.x · Cited by 147
Regulation of Mitochondrial Respiration by Oxygen and Nitric Oxide
BOVERIS, A., Costa, L. E., Poderoso, J. J., Carreras, M. C., & Cadenas, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06181.x · Cited by 148
Sex hormone-induced prostatic carcinogenesis in the Noble rat: The role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of prostate cancer
Wang, Y. Z., & Wong, Y. C. (1998) · The Prostate · doi:10.1002/(sici)1097-0045(19980515)35:3 · Cited by 123
Ratiometric Electrochemical Sensor for Effective and Reliable Detection of Ascorbic Acid in Living Brains
Cheng, H., Wang, X., & Wei, H. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02014 · Cited by 145
Biochemistry of Nitric Oxide
Habib, S., & Ali, A. (2011) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-011-0108-4 · Cited by 144
Characterization and function of mitochondrial nitric-oxide synthase
Giulivi, C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01298-4 · Cited by 144
Mitochondrial Ca2+ and the heart
Dedkova, E. N., & Blatter, L. A. (2008) · Cell Calcium · doi:10.1016/j.ceca.2007.11.002 · Cited by 147
Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition
DILISA, F., & BERNARDI, P. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.009 · Cited by 139
Therapeutic potential of nitric oxide in cancer
Bonavida, B., KHINECHE, S., Huerta‐Yépez, S., & Garbán, H. (2006) · Drug Resistance Updates · doi:10.1016/j.drup.2006.05.003 · Cited by 141
Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase
Janes, K., Doyle, T. M., Bryant, L., Esposito, E., Cuzzocrea, S., Ryerse, J. S., Bennett, G. J., & Salvemini, D. (2013) · Pain · doi:10.1016/j.pain.2013.07.032 · Cited by 139
Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome c oxidase
Brookes, P., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00805-x · Cited by 137
Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm
Lucca, G., Comim, C. M., Valvassori, S. S., Réus, G. Z., Vuolo, F. S., Petronilho, F. C., Gavioli, E. C., Dal‐Pizzol, F., & Quevedo, J. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.11.002 · Cited by 138
[20] Regulation of mitochondrial respiration by adenosine diphosphate, oxygen, and nitric oxide
Boveris, A., Costa, L. E., Cadenas, E., & Poderoso, J. J. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)01082-4 · Cited by 137
Long‐term melatonin administration protects brain mitochondria from aging
Carretero, M., Escames, G., López, L. C., Venegas, C., Dayoub, J. C., García‐Corzo, L., & Acuña-Castroviejo, D. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00700.x · Cited by 135
S-Nitrosoglutathione as a substrate for γ-glutamyl transpeptidase
Hogg, N., Singh, R., Konorev, E. A., Joseph, J., & Kalyanaraman, B. (1997) · Biochemical Journal · doi:10.1042/bj3230477 · Cited by 136
Haloperidol- and clozapine-induced oxidative stress in the rat brain
Polydoro, M., Schröder, N., de Lima, M. N. M., Caldana, F., Laranja, D. C., Bromberg, E., Roesler, R., Quevedo, J., Moreira, J. C. F., & Dal‐Pizzol, F. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.05.018 · Cited by 134
Fighting the stranger—antioxidant protection against endotoxin toxicity
Cadenas, S. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00381-5 · Cited by 135
CO from enhanced HO activity or from CORM-2 inhibits both O2− and NO production and downregulates HO-1 expression in LPS-stimulated macrophages
Srisook, K., Han, S.-S., Choi, H.-S., Li, M., UEDA, H. M. D., Kim, C., & Cha, Y. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.042 · Cited by 134
Interaction of Peroxynitrite with Mitochondrial Cytochrome Oxidase
Sharpe, M. A., & Cooper, C. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30961 · Cited by 133
Cytopathic hypoxia: Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?
Fink, M. P. (2002) · Critical Care Clinics · doi:10.1016/s0749-0704(03)00071-x · Cited by 133
Peroxiredoxins play a major role in protectingTrypanosoma cruziagainst macrophage- and endogenously-derived peroxynitrite
Piacenza, L., Peluffo, G., Álvarez, M. N., Kelly, J. M., Wilkinson, S. R., & Radí, R. (2008) · Biochemical Journal · doi:10.1042/bj20071138 · Cited by 132
Gold nanoparticles prevent cognitive deficits, oxidative stress and inflammation in a rat model of sporadic dementia of Alzheimer's type
Muller, A. P., Ferreira, G. K., Pires, A. J., Silveira, G. D. B., de Souza, D. L., Brandolfi, J. D. A., de Souza, C. T., Paula, M. M. D. S., & Silveira, P. C. L. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.283 · Cited by 132
Bradykinin receptor gene variant and human physical performance
Williams, A. G., Dhamrait, S. S., Wootton, P. T. E., Day, S. H., Hawe, E., Payne, J. R., Myerson, S. G., WORLD, M. J., Budgett, R., Humphries, S. E., et al. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00865.2003 · Cited by 132
Nitric oxide preserves the level of chlorophyll in potato leaves infected by Phytophthora infestans
Lazalt, A. M., Beligni, M. V., & Lamattina, L. (1997) · European Journal of Plant Pathology · doi:10.1023/a:1008604410875 · Cited by 129
Mitochondrial nitric oxide in the signaling of cell integrated responses
Carreras, M. C., & Poderoso, J. J. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00248.2006 · Cited by 128
Diabetes, Oxidative Stress, Nitric Oxide and Mitochondria Function
Friederich, M., Hansell, P., & Palm, F. (2009) · Current Diabetes Reviews · doi:10.2174/157339909788166800 · Cited by 128
Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart
Akhmedov, A. T., Rybin, V. O., & Marín-García, J. (2014) · Heart Failure Reviews · doi:10.1007/s10741-014-9457-4 · Cited by 128
Kinetics of the inhibition of mitochondrial respiration by NO
Koivisto, A., Matthias, A., Bronnikov, G. E., & Nedergaard, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01258-1 · Cited by 126
Nitric Oxide Induces Cell Death by Regulating Anti-Apoptotic BCL-2 Family Members
Snyder, C. M., Shroff, E. H., Liu, J., & Chandel, N. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007059 · Cited by 123
From Mitochondria to Disease: Role of the Renin-Angiotensin System
de Cavanagh, E. M. V., Inserra, F., Ferder, M., & Ferder, L. (2007) · American Journal of Nephrology · doi:10.1159/000107757 · Cited by 124
Direct Evidence of Nitric Oxide Presence within Mitochondria
López-Figueroa, M. O., Caamaño, C. A., Morano, M. I., Rønn, L. C. B., Akil, H., & Watson, S. J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2748 · Cited by 124
Nitric Oxide in Skeletal Muscle: Role on Mitochondrial Biogenesis and Function
Tengan, C., Rodrigues, G., & Godinho, R. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131217160 · Cited by 123
Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
Xing, B., Xin, T., Hunter, R. L., & Bing, G. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-4 · Cited by 123
Mitochondria: Redox Metabolism and Dysfunction
Kang, J., & Pervaiz, S. (2012) · Biochemistry Research International · doi:10.1155/2012/896751 · Cited by 124
The emerging roles of nitric oxide (NO) in plant mitochondria
Gupta, K. J., Igamberdiev, A. U., Manjunatha, G., Segu, S., Morán, J. F., Neelawarne, B., Bauwe, H., & Kaiser, W. M. (2011) · Plant Science · doi:10.1016/j.plantsci.2011.03.018 · Cited by 119
Control of Mitochondrial Respiration by NO., Effects of Low Oxygen and Respiratory State
Brookes, P. S., Kraus, D. W., Shiva, S., Doeller, J. E., Barone, M.-C., Patel, R. P., Lancaster, J. R., & Darley-Usmar, V. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211784200 · Cited by 118
Recognition memory impairment and brain oxidative stress induced by postnatal iron administration
de Lima, M. N. M., Polydoro, M., Laranja, D. C., Bonatto, F., Bromberg, E., Moreira, J. C. F., Dal‐Pizzol, F., & Schröder, N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04083.x · Cited by 119
The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice
Venkatraman, A., Shiva, S., Wigley, A., Ulasova, E., Chhieng, D., Bailey, S. M., & Darley-Usmar, V. M. (2004) · Hepatology · doi:10.1002/hep.20326 · Cited by 117
Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells
de Oliveira, M. R., Ferreira, G. C., Schuck, P. F., & Bosco, S. M. D. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.11.003 · Cited by 116
Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species
Giedt, R. J., Yang, C., Zweier, J. L., Anastasios Matzavinos, A., & Alevriadou, B. R. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.491 · Cited by 113
The Biological Chemistry of Peroxynitrite
Radí, R., Denicola, A., Álvarez, B., Ferrer‐Sueta, G., & Rubbo, H. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50005-8 · Cited by 115
PLA2dependence of diaphragm mitochondrial formation of reactive oxygen species
Nethery, D. E., Callahan, L. A., Stofan, D. A., Mattera, R., DiMarco, A. F., & Supinski, G. S. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.72 · Cited by 115
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113
Genomics of elite sporting performance: what little we know and necessary advances
Pitsiladis, Y. P., Wang, G., Wolfarth, B., Scott, R. A., Fuku, N., Miyamoto‐Mikami, E., He, Z., Fiuza‐Luces, C., Eynon, N., & Lucía, A. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092400 · Cited by 117
Nitric Oxide, Superoxide, and Hydrogen Peroxide Production in Brain Mitochondria after Haloperidol Treatment
Arnaiz, S. L., Coronel, M. F., & Boveris, A. (1999) · Nitric Oxide · doi:10.1006/niox.1999.0229 · Cited by 113
Modulation of the Mitochondrial Permeability Transition by Nitric Oxide
Balakirev, M. Y., Khramtsov, V. V., & Zimmer, G. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00710.x · Cited by 112
Mechanisms of Cell Signaling by Nitric Oxide and Peroxynitrite: From Mitochondria to MAP Kinases
Levonen, A., Patel, R. P., Brookes, P. S., Go, Y., Jo, H., Parthasarathy, S., Anderson, P. G., & Darley-Usmar, V. M. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601300185188 · Cited by 113
Adventures in vascular biology: a tale of two mediators
Moncada, S. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1775 · Cited by 110
Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise
da Silva, L. A., Silveira, P. C. L., Ronsani, M. M., de Souza, P. S., Scheffer, D. D. L., Vieira, L. C., Benetti, M., de Souza, C. T., & Pinho, R. A. (2010) · Cell Biochemistry and Function · doi:10.1002/cbf.1716 · Cited by 111
The Relationship Between Reactive Oxygen Species and Endothelial Cell Metabolism
Alhayaza, R., Haque, E., Karbasiafshar, C., Sellke, F. W., & Abid, M. R. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.592688 · Cited by 116
Role of calcium signaling in the activation of mitochondrial nitric oxide synthase and citric acid cycle
Traaseth, N. J., Elfering, S. L., Solien, J., Haynes, V. L., & Giulivi, C. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.04.015 · Cited by 110
Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK
Xu, Z., Ji, X., & Boysen, P. G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00882.2003 · Cited by 111
Anoxic nitric oxide cycling in plants: participating reactions and possible mechanisms
Igamberdiev, A. U., Bykova, N. V., Shah, J. K., & Hill, R. D. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01314.x · Cited by 115
Nitric oxide as a competitive inhibitor of oxygen consumption in the mitochondrial respiratory chain
Brown, G. C. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00718.x · Cited by 108
Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome
Pall, M. L. (2000) · Medical Hypotheses · doi:10.1054/mehy.1998.0825 · Cited by 107
Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice
López, L. C., Escames, G., Tapias, V., Utrilla, P., León, J., & Acuña-Castroviejo, D. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.09.008 · Cited by 107
Endothelial Cell Energy Metabolism, Proliferation, and Apoptosis in Pulmonary Hypertension
Xu, W., & ERZURUM, S. C. (2010) · Comprehensive physiology · doi:10.1002/cphy.c090005 · Cited by 123
Melatonin, clock genes and mitochondria in sepsis
Acuña-Castroviejo, D., Rahim, I., Acuña‐Fernández, C., Fernández‐Ortiz, M., Marín, J. S., Sayed, R. K. A., Díaz-Casado, M. E., Rusanova, I., López, L. C., & Escames, G. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2610-1 · Cited by 115
Role of poly(ADP-ribose)synthetase in inflammation
Szabó, C. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00249-0 · Cited by 106
Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts
Novalija, E., Varadarajan, S. G., Camara, A. K. S., An, J., Chen, Q., Riess, M. L., Hogg, N., & Stowe, D. F. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01056.2001 · Cited by 105
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome
Gómez, C. (2006) · Frontiers in bioscience · doi:10.2741/2128 · Cited by 104
Mitochondria and vascular pathology
Lisa, F. D., Kaludercic, N., Carpi, A., Menabò, R., & Giorgio, M. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70014-3 · Cited by 106
Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles
Forman, H. J., Torrès, M., & Fukuto, J. (2003) · Springer eBooks · doi:10.1007/0-306-48412-9 · Cited by 104
Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation
Hongo, F., Garbán, H., Huerta‐Yépez, S., Vega, M. I., Jazirehi, A. R., Mizutani, Y., Miki, T., & Bonavida, B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.150 · Cited by 105
Cancer cell metabolism and the modulating effects of nitric oxide
Chang, C.-F., Diers, A. R., & Hogg, N. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.012 · Cited by 103
Oxidative stress in the brain of nicotine-induced toxicity: protective role ofAndrographis paniculataNees and vitamin E
Das, S., Gautam, N., Dey, S. K., Maiti, T., & Roy, S. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h08-147 · Cited by 102
The Modulation of Mitochondrial Nitric-oxide Synthase Activity in Rat Brain Development
Galdo, N. A. R., Melani, M., Sanjuan, N. A., Fiszman, M. L., Gravielle, M. C., Carreras, M. C., Cadenas, E., & Poderoso, J. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204580200 · Cited by 102
The Chemical Biology of Nitric Oxide
Wink, D. A., Feelisch, M., Yoram Vodovotz, B., Fukuto, J. M., & Grisham, M. B. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46806-9_10 · Cited by 102
Mitochondrial protein tyrosine nitration
Castro, L., Demicheli, V., Tórtora, V., & Radí, R. (2010) · Free Radical Research · doi:10.3109/10715762.2010.516254 · Cited by 101
Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome
Morris, G., Berk, M., Klein, H. C., Walder, K. R., Gałecki, P., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9975-2 · Cited by 100
Acute Effects of Nitric Oxide and Cyclic GMP on Human Myocardial Contractility
Flesch, M., Kilter, H., Cremers, B., Lenz, O., Südkamp, M., Kuhn‐Régnier, F., & Böhm, M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36716-3 · Cited by 97
Dissecting the integrative antioxidant and redox systems in plant mitochondria. Effect of stress and S-nitrosylation
Lázaro, J. J., Jiménez, A., Camejo, D. M., Iglesias-Baena, I., Martí, M. C., Lázaro-Payo, A., Barranco-Medina, S., & Sevilla, F. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00460 · Cited by 98
Changing Paradigms in Thiology
Flohé, L. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)73001-9 · Cited by 100
Mitochondrial DNA and inflammatory diseases
Escames, G., López, L. C., García, J. A., García‐Corzo, L., Ortiz, F., & Acuña-Castroviejo, D. (2011) · Human Genetics · doi:10.1007/s00439-011-1057-y · Cited by 97
Nitric oxide is involved in anoxic preconditioning neuroprotection in rat hippocampal slices
Centeno, J. M., Ortı́, M., Salom, J. B., Sick, T. J., & Pérez‐Pinzón, M. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01610-8 · Cited by 96
The Catabolic Fate of Nitric Oxide
Pearce, L. L., Kanai, A., Birder, L. A., Pitt, B. R., & Peterson, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109838200 · Cited by 96
Reactive Oxygen and Nitrogen Species Regulate Mitochondrial Ca2+ Homeostasis and Respiration
Richter, C. (1997) · Bioscience Reports · doi:10.1023/a:1027387301845 · Cited by 97

Authors: Poderoso, J. J., Carreras, M. C., Lisdero, C., Riobó, N., Schöpfer, F., & Boveris, A.
Affiliations: Universidad de Buenos Aires (AR)
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 1996-04
Volume: 328
Issue: 1
Pages: 85-92
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1006/abbi.1996.0146
OpenAlex: W2070235240
Cited by: 726
References: 1
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 11 · 2021: 14 · 2020: 16 · 2019: 23 · 2018: 18 · 2017: 18 · 2016: 23 · 2015: 20 · 2014: 20 · 2013: 27 · 2012: 45
FWCI: 7.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: nitric oxide, S-nitrosoglutathione, heart mitochondria, submitochondrial particles, cytochrome c oxidase inhibition, electron transfer inhibition, hydrogen peroxide production, peroxynitrite, superoxide dismutase, electron transport chain
MeSH terms: Animals, Electron Transport Complex IV, Electron Transport, Female, Mitochondria, Heart, NAD, NADH Dehydrogenase, Nitric Oxide, Submitochondrial Particles, Succinates, Superoxides, Rats, Sprague-Dawley, Ion-Selective Electrodes, Succinic Acid, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks