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Cited by 712Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesPomegranate: compositions and health benefits

The DOI matches its Crossref record.

Lycopene: A Biologically Important Carotenoid for Humans?

Stahl, Wilhelm, Sies, Helmut·1996·Archives of Biochemistry and Biophysics
DOI 10.1006/abbi.1996.0525
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Abstract

Lycopene is a carotenoid present in human blood (approximately 0.5 micromol/liter plasma), and the tissue levels vary from 1 nmol/g wet wt in adipose tissue to up to 20 nmol/g wet wt in adrenals and testes. Its biological activities include antioxidant activity (singlet oxygen quenching and peroxyl radical scavenging), induction of cell-cell communication, and growth control, but no provitamin A activity. Epidemiological studies suggest protective effects of lycopene on some types of cancer, e.g., prostate cancer. In vitro and in vivo studies on growth of tumor cells support this conclusion. The major sources of lycopene for the human are tomatoes and tomato products, and bioavailability from different food items varies considerably. Lycopene oxidation products have recently been identified in human serum. Suggested health effects of lycopene require further investigation.

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Metadata

Authors
Stahl, W., & Sies, H.
Affiliations
Heinrich Heine University Düsseldorf (DE)
Corresponding author
Sies, Helmut
ORCID
Venue
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Published
1996-12
Volume
336
Issue
1
Pages
1-9
ISSN
0003-9861 (ISSN-L)
DOI
10.1006/abbi.1996.0525
OpenAlex
W1981682289
Cited by
712
References
0
Citations by year
2026: 8 · 2025: 5 · 2024: 15 · 2023: 23 · 2022: 20 · 2021: 16 · 2020: 15 · 2019: 23 · 2018: 23 · 2017: 29 · 2016: 30 · 2015: 35 · 2014: 26 · 2013: 30 · 2012: 22
FWCI
11.39
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Biochemistry and Biophysics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords
lycopene, carotenoids, antioxidant activity, singlet oxygen quenching, peroxyl radical scavenging, intercellular communication, growth regulation, chemoprevention, prostate cancer, tissue distribution, bioavailability, tomato, human serum
MeSH terms
Lycopene, Antioxidants, Carotenoids, Diet, Humans, Tissue Distribution, beta Carotene

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