Microtubule-Associated Protein Interactions with Actin Filaments: Evidence for Differential Behavior of Neuronal MAP-2 and Tau in the Presence of Phosphatidylinositol
Abstract
Microtubule-associated protein (MAP) interactions with actin were investigated by falling-ball viscometry. At 1-2 microM MAP-2 or tau, we obtained a critical gelation concentration for actin of 0.1 mg/ml. In the presence of phosphatidyl-inositol, actin filament bundling was completely disrupted only when MAP-2 served as the cross-linker, whereas tau-induced bundling of actin was unaffected by phosphatidyl-inositol. This represents the first clear indication that MAP-2 and tau exhibit differential behavior in their interaction with cytoskeletal components.
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MAPs bundle actin filaments and cross-link the cellular cytoskeleton formed by microtubules and actin filaments.
“In addition, MAPs bundle actin filaments and cross-link the cellular cytoskeleton formed by microtubules and actin filaments (Fig. 1a)3–10.”
From Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau (2017) · cites this paper as [3]
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Cabrales Fontela, Y., Kadavath, H., Biernat, J., Riedel, D., Mandelkow, E., & Zweckstetter, M. (2017) · Nature Communications · doi:10.1038/s41467-017-02230-8 · Cited by 148 · see citing works
Wei, Y., Qu, M.-H., Wang, X.-S., Chen, L., Wang, D.-L., Liu, Y., Hua, Q., & He, R.-Q. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002600 · Cited by 129 · see citing works
- Authors
- Yamauchi, P. S., & Purich, D. L.
- Affiliations
- University of Florida (US)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1993-02
- Volume
- 190
- Issue
- 3
- Pages
- 710-715
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1975237969
- Cited by
- 36
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 3 · 2015: 1 · 2012: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm044823-04)
- National Institute of General Medical Sciences (GM-44823)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- microtubule-associated proteins, MAP2, tau protein, F-actin, actin bundling, phosphatidylinositol, cytoskeletal interactions, critical gelation concentration, neuronal cytoskeleton
- MeSH terms
- Actins, Animals, Cattle, Microfilament Proteins, Microtubule-Associated Proteins, Nerve Tissue Proteins, Phosphatidylinositols, Protein Binding, Rabbits, Viscosity, tau Proteins, In Vitro Techniques
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