The DOI matches its Crossref record.
Non-age Related Differences in Thrombin Responses by Platelets from Male Patients with Advanced Alzheimer′s Disease
Open accessAbstract
Alzheimer's Disease(AD), characterized by a deposition of beta-amyloid peptide (beta/A4) in the brain and in the cerebral microvasculature of affected individuals, is derived from its precursor protein (beta APP) via proteolytic processing by enzyme(s) which have not yet been characterized or localized. Since platelets carry APP in one of their granules, they have been implicated as a source of the beta/A4 deposits in the microvasculature of AD patients, attributable to either an abnormality in the platelets' stimulus response, in the quantity or nature of the APP they release upon activation and/or in the processing of that protein. We show here that platelets from patients with severe AD have abnormal stimulus responses to alpha-thrombin. Specifically, these cells hyperacidify. While it is not clear why this abnormality occurs, it may contribute to aberrant granule secretion since we have demonstrated earlier that release of platelet granule contents is partially controlled by the cytoplasmic pH.
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Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Metadata
- Authors
- Davies, T. A., Fine, R. E., Johnson, R. J., Levesque, C. A., Rathbun, W. H., Seetoo, K. F., Smith, S. J., Strohmeier, G., Volicer, L., Delva, L., & Simons, E. R.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1993-07
- Volume
- 194
- Issue
- 1
- Pages
- 537-543
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2161457330
- Cited by
- 234
- References
- 0
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Davies, T. A., Fine, R. E., Johnson, R. J., Levesque, C. A., Rathbun, W. H., Seetoo, K. F., Smith, S. J., Strohmeier, G., Volicer, L., Delva, L., & Simons, E. R. (1993). Non-age Related Differences in Thrombin Responses by Platelets from Male Patients with Advanced Alzheimer′s Disease. Biochemical and Biophysical Research Communications. https://doi.org/10.1006/bbrc.1993.1853
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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