Attachment and growth of fibroblast cells on silk fibroin
Abstract
The attachment and growth of fibroblast cells (L-929) on matrices of silk fibroin from Bombyx mori domestic silkworm (DSF) and Antheraea pernyi wild silkworm (WSF) were studied by a cell culture method. The performance of the two kinds of silk fibroin was compared to that of collagen. DSF exhibited as high a cell attachment and growth as collagen did. The cells attached to DSF were extensively spread out and their filopodia were visible in the SEM pictures. WSF, which contains the tripeptide sequence Arg-Gly-Asp (believed to be a specific interaction site for cell-attachment), displayed much higher cell attachment and growth compared to DSF. The cells attached on WSF became virtually flat and their filopodia could be seen, indicating that the cells were very strongly held on the surface.
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Bombyx mori silkworm silk fibroin is highly biocompatible due to its structure and chemical composition.
“Bombyx mori silkworm silk fibroin is highly biocompatible due to its structure and chemical composition.”
From Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review (2025) · cites this paper as [25]
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Cited by 371
- Authors
- Minoura, N., Aiba, S. I., Higuchi, M., Gotoh, Y., Tsukada, M., & Imai, Y.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1995-03
- Volume
- 208
- Issue
- 2
- Pages
- 511-516
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2076828256
- Cited by
- 371
- References
- 0
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 12 · 2023: 5 · 2022: 12 · 2021: 19 · 2020: 10 · 2019: 13 · 2018: 16 · 2017: 15 · 2016: 21 · 2015: 22 · 2014: 26 · 2013: 19 · 2012: 27
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- silk fibroin, cell growth, Bombyx mori, Antheraea pernyi, collagen, cell spreading, filopodia, biomaterial surfaces
- MeSH terms
- Amino Acid Sequence, Animals, Biocompatible Materials, Cell Adhesion, Cell Division, Cells, Cultured, Collagen, Fibroblasts, Fibroins, L Cells, Molecular Sequence Data, Bombyx, Mice, In Vitro Techniques
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