Amyloid P Component Promotes Aggregation of Alzheimer′s β-Amyloid Peptide
Abstract
Amyloid P component (AP) has been recognized as a beta-amyloid-associated protein but the pathological role is not known. In the present experiments, it has been shown that AP promotes the aggregation of Alzheimer's beta-amyloid peptide (A beta) in the presence of a physiological concentration of Ca2+. The aggregation promotion was observed at a concentration of soluble A beta 1-40 in human cerebrospinal fluid. The results suggest that AP is possibly a pathogenic factor of the cerebral amyloidosis.
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The binding of SAP stabilizes amyloid fibrils and promotes their formation in the brain, thereby contributing to the pathogenesis of AD and cerebral amyloid angiopathy.
“The binding of SAP stabilizes amyloid fibrils85 and promotes their formation in the brain86,87, thereby contributing to the pathogenesis of AD and cerebral amyloid angiopathy88,89.”
From Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis (2025) · cites this paper as [87]
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Cited by 50
- Authors
- Hamazaki, H.
- Affiliations
- Kitasato University (JP)
- Corresponding author
- Hamazaki, H.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 211
- Issue
- 2
- Pages
- 349-353
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2118151073
- Cited by
- 50
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- serum amyloid P component, beta-amyloid peptide, amyloid fibril formation, calcium, Aβ40, cerebrospinal fluid, cerebral amyloidosis, Alzheimer's disease, pathogenic factors
- MeSH terms
- Serum Amyloid P-Component, Humans, Kinetics, Zinc, Amyloid beta-Protein Precursor
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