Isolation, Chemical Characterization, and Quantitation of Aβ 3-Pyroglutamyl Peptide from Neuritic Plaques and Vascular Amyloid Deposits

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Items 101–178 of 178

1. Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation
   Yutaka Sadakane, Masahiro Kawahara · 2018 · International Journal of Molecular Sciences
2. Post‐translational protein arginylation in the normal nervous system and in neurodegeneration
   Mauricio Raul Galiano, Victor E. Goitea, Marta Elena Hallak · 2016 · Journal of Neurochemistry
3. Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
   Srinivas Koutarapu, Junyue Ge, Maciej Dulewicz, Meera Srikrishna, Alicja Szadziewska, Jack I. Wood, Kaj Blennow, Henrik Zetterberg, Wojciech Michno, Natalie Sarah Ryan et al. · 2025 · Nature Communications
4. Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes
   Philipp Spitzer, Martin Herrmann i, Hans‐Wolfgang Klafki, Smirnov Av, Piotr Lewczuk, Johannes Kornhuber, Jens Wiltfang, Juan Manuel Maler · 2010 · Journal of Neuroinflammation
5. Familial Presenilin Mutations and Sporadic Alzheimer’s Disease Pathology: Is the Assumption of Biochemical Equivalence Justified?
   Alex E. Roher, Chera L. Maarouf, Tyler A. Kokjohn · 2016 · Journal of Alzheimer s Disease
6. [7] Chemical modifications of deposited amyloid-β peptides
   Jonathan D. Lowenson, Steven Gerard Clarke, Alex E. Roher · 1999 · Methods in enzymology on CD-ROM/Methods in enzymology
7. Amyloid-beta peptide Aβp3-42 affects early aggregation of full-length Aβ1-42
   Hiromi M. Sanders, Robert M. Lust, Jan K. Teller · 2009 · Peptides
8. Unmodified and pyroglutamylated amyloid β peptides form hypertoxic hetero‐oligomers of unique secondary structure
   Greg Goldblatt, Lucia Cilenti, Jason O. Matos, Briana Lee, Nicholas Ciaffone, Qing X. Wang, Laurène Tétard, Ken Teter, Suren A. Tatulian · 2017 · FEBS Journal
9. Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides
   Greg Goldblatt, Jason O. Matos, Jeremy Gornto, Suren A. Tatulian · 2015 · Physical Chemistry Chemical Physics
10. Functions of glutaminyl cyclase and its isoform in diseases
    Yue Liu, Yufeng Shi, Ping Wang · 2023 · Visualized Cancer Medicine
11. Characterizing Aging, Mild Cognitive Impairment, and Dementia with Blood-Based Biomarkers and Neuropsychology
    Martin Kleinschmidt, Robby Schoenfeld, Claudia Göttlich, Daniel Bittner, Jürgen Erich Metzner, Bernd Leplow, Hans‐Ulrich Demuth · 2016 · Journal of Alzheimer s Disease
12. Mouse strain and brain region‐specific expression of the glutaminyl cyclases QC and isoQC
    Corinna Höfling, Henrike Indrischek, Theodor Höpcke, Alexander Waniek, Holger Cynis, Birgit Maria Koch, Stephan Schilling, Markus Morawski, Hans‐Ulrich Demuth, Steffen Roßner et al. · 2014 · International Journal of Developmental Neuroscience
13. In vitro and in silico determination of glutaminyl cyclase inhibitors
    Phuong‐Thao Tran, Van-Hai Hoang, Jeewoo Lee, Trần Thị Thu Hiền, Nguyễn Thanh Tùng, Sơn Tùng Ngô · 2019 · RSC Advances
14. A QM/MM study of the molecular recognition site of bapineuzumab toward the amyloid-β peptide isoforms
    Lucas Joel Gutiérrez, Exequiel Barrera, Nélida M. Peruchena, Ricardo Daniel Enriz · 2015 · Molecular Simulation
15. Refining the amyloid β peptide and oligomer fingerprint ambiguities in Alzheimer’s disease: Mass spectrometric molecular characterization in brain, cerebrospinal fluid, blood, and plasma
    Wojciech Michno, Kaj Blennow, Henrik Zetterberg, Gunnar Brinkmalm · 2021 · Journal of Neurochemistry
16. Cryo-EM structures of cotton wool plaques’ amyloid β and of tau filaments in dominantly inherited Alzheimer disease
    Md Rejaul Hoq, Anllely Fernández, Frank S. Vago, Grace I. Hallinan, S.R. Bharath, Daoyi Li, Kadir A. Ozcan, Holly J. Garringer, Wen Jiang, Rubén Vidal et al. · 2024 · Acta Neuropathologica
17. Antemortem-Postmortem Correlation of Florbetapir ( 18 F) PET Amyloid Imaging with Quantitative Biochemical Measures of Aβ 42 but not Aβ 40
    Thomas G. Beach, Chera L. Maarouf, Anthony J. Intorcia, Lucia I. Sue, Geidy E. Serrano, Ming‐Chi Lu, Abhinay D. Joshi, Michael J. Pontecorvo, Alex E. Roher · 2018 · Journal of Alzheimer s Disease
18. PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation
    Mercedes Arnés, Ninovska Romero, Sergio Casas‐Tintó, Ángel Acebes, Alberto Ferrús · 2019 · Molecular Biology of the Cell
19. Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice
    Xiaojuan Wang, Li Wang, Xi Yu, Yue Li, Zhigang Liu, Yongdong Zou, Yizhi Zheng, Zhendan He, Haiqiang Wu · 2019 · International Immunopharmacology
20. Neuron Loss and Behavioral Deficits in the TBA42 Mouse Model Expressing N-Truncated Pyroglutamate Amyloid-β3–42
    Meißner, Julius N., Bouter, Yvonne, Bayer, Thomas A. · 2015 · Journal of Alzheimer s Disease
21. Synthesis and evaluation of [ 11 C]PBD150, a radiolabeled glutaminyl cyclase inhibitor for the potential detection of Alzheimer's disease prior to amyloid β aggregation
    Allen Frederick Brooks, Isaac M. Jackson, Xia Shao, George Kropog, Phillip S. Sherman, Carole Quesada, Peter J. H. Scott · 2015 · MedChemComm
22. Structures of Aβ-Related Peptide−Monoclonal Antibody Complexes,
    Anna S. Gardberg, Lezlee T. Dice, Kathleen Pridgen, Jan Ko, Paul H. Patterson, Susan Ker-hwa Ou, Ronald B. Wetzel, Chris Godfrey Dealwis · 2009 · Biochemistry
23. Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease
    Oliver Kupski, Lisa-Marie Funk, V. Sautner, Franziska Seifert, Brigitte Worbs, Daniel Ramsbeck, Franc Meyer, Ulf Diederichsen, Mirko Buchholz, Stephan Schilling et al. · 2020 · Biochemistry
24. Site-specific chirality-conferred structural compaction differentially mediates the cytotoxicity of Aβ42
    Gongyu Li, Chae Kyung Jeon, Mengyao Ma, Yifei Jia, Zhen Zheng, Daniel G. Delafield, Gaoyuan Lu, Elena V. Romanova, Jonathan V. Sweedler, Brandon T. Ruotolo et al. · 2023 · Chemical Science
25. Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer’s disease, dementia with Lewy bodies and vascular dementia
    Sarah Schrempel, Anna Katharina Kottwitz, Anke Piechotta, Kathrin Gnoth, Luca Büschgens, Maike Hartlage‐Rübsamen, Markus Morawski, Mathias Schenk, Martin Kleinschmidt, Geidy E. Serrano et al. · 2024 · Acta Neuropathologica
26. In silico exploration of the fingerprints triggering modulation of glutaminyl cyclase inhibition for the treatment of Alzheimer’s disease using SMILES based attributes in Monte Carlo optimization
    Ashwani Kumar, Kiran Bagri, Manisha Nimbhal, Prof Parvin Kumar · 2020 · Journal of Biomolecular Structure and Dynamics
27. Enhanced ion mobility resolution of Abeta isomers from human brain using high-resolution demultiplexing software
    Soumya Mukherjee, John C. Fjeldsted, Colin Louis Masters, Blaine Russell Roberts · 2022 · Analytical and Bioanalytical Chemistry
28. On-line high-performance liquid chromatography/mass spectrometric investigation of amyloid-β peptide variants found in Alzheimer's disease
    Andrew Thompson, Teck Kwang Lim, Colin James Barrow · 1999 · Rapid Communications in Mass Spectrometry
29. Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice
    Tina Dunkelmann, Sarah Schemmert, Dominik Honold, Kerstin Teichmann, Elke Butzküven, Hans‐Ulrich Demuth, Nadim Jon Shah, Karl‐Josef Langen, Janine Kutzsche, Dieter Willbold et al. · 2018 · Journal of Alzheimer s Disease
30. Methods for the isolation and analysis of Aβ from postmortem brain
    Wei Hong, Wen Liu, Alexandra DeSousa, Tracy L. Young‐Pearse, Dominic M. Walsh · 2023 · Frontiers in Neuroscience
31. Astrocytic uptake of posttranslationally modified amyloid‐β leads to endolysosomal system disruption and induction of pro‐inflammatory signaling
    Sarah Wirth, Annika Schlößer, Antonia Beiersdorfer, Michaela Schweizer, Marcel S. Woo, Manuel Alexander Friese, Christian Lohr, Katarzyna M. Grochowska · 2024 · Glia
32. Identifying hQC Inhibitors of Alzheimer’s Disease by Effective Customized Pharmacophore-Based Virtual Screening, Molecular Dynamic Simulation, and Binding Free Energy Analysis
    Weicong Lin, Xiaojie Zheng, Danqing Fang, Shengfu Zhou, Wenjuan Wu, Kang‐Cheng Zheng · 2018 · Applied Biochemistry and Biotechnology
33. Unveiling Brain Aβ Heterogeneity Through Targeted Proteomic Analysis
    Agueda A. Rostagno, Thomas A. Neubert, Jorge A. Ghiso · 2018 · Methods in molecular biology
34. Involvement of polyglutamine endolysis followed by pyroglutamate formation in the pathogenesis of triplet repeat/polyglutamine-expansion diseases
    Takaomi C. Saido · 2000 · Medical Hypotheses
35. Of mice and men: The relevance of transgenic mice Aβ immunizations to Alzheimer's disease
    Alex E. Roher, Tyler A. Kokjohn · 2002 · Journal of Alzheimer s Disease
36. Pharmacokinetic evaluation of donanemab for the treatment of Alzheimer’s
    Tanya Song, Yunfei Wang, Bret Silverglate, George Thomas Grossberg · 2024 · Expert Opinion on Drug Metabolism & Toxicology
37. Adherence-dependent shifts in the patterns of β-amyloid peptides secreted by human mononuclear phagocytes
    Juan Manuel Maler, Philipp Spitzer, Hans‐Wolfgang Klafki, Hermann Esselmann, Mirko Bibl, Piotr Lewczuk, Johannes Kornhuber, Martin Herrmann i, Jens Wiltfang · 2008 · Brain Behavior and Immunity
38. Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death
    Jeffrey N. Keller, William R. Markesbery · 2000 · Journal of Neuroscience Research
39. Novel monoclonal antibody 3B8 specifically recognizes pyroglutamate-modified amyloid β 3-42 peptide in brain of AD patients and 3xTg-AD transgenic mice
    Gonzalo Acero, Claudia Angélica Garay-Canales, David Venegas, Enrique Ortega, Goar Gevorkian · 2020 · Neuroscience Letters
40. Hybrid descriptors–conjoint indices: a case study on imidazole-thiourea containing glutaminyl cyclase inhibitors for design of novel anti-Alzheimer’s candidates
    Kiran Bagri, Archana Kapoor, Prof Parvin Kumar, Ashwani Kumar · 2023 · SAR and QSAR in environmental research
41. Pyroglutamate-Amyloid-β and Glutaminyl Cyclase Are Colocalized with Amyloid-β in Secretory Vesicles and Undergo Activity-Dependent, Regulated Secretion
    Holger Cynis, Lydiane Funkelstein, Thomas Toneff, Charles Mosier, Michael G. Ziegler, Birgit Koch, Hans‐Ulrich Demuth, VIVIAN Y. H. HOOK · 2014 · Neurodegenerative Diseases
42. Role of Posttranslational Modifications in Amyloid Formation
    Andisheh Abedini, Ruchi Gupta, Peter Marek, Fanling Meng, Daniel P. Raleigh, Humeyra Taskent‐Sezgin, Sylvia M. Tracz · 2010
43. Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab
    Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya et al. · 2024 · Life Science Alliance
44. Verstärkte Fibrillen‐Fragmentierung N‐terminal verkürzter, Pyroglutamat‐modifizierter Aβ‐Peptide
    Melanie Wulff, Monika Baumann, Anka Thümmler, Jay Kant Yadav, Liesa Heinrich, Uwe Knüpfer, Dagmar Schlenzig, Angelika Schierhorn, Jens‐Ulrich Rahfeld, Uwe Horn et al. · 2016 · Angewandte Chemie
45. Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer’s Disease
    Soumya Kandi, Erika N. Cline, Brianna M. Rivera, Kirsten L. Viola, Jiuhe Zhu, Carlo Condello, Richard D. LeDuc, William L. Klein, Neil L. Kelleher, Steven M. Patrie · 2023 · Journal of Proteome Research
46. Neuropathology of Alzheimer’s disease in Down syndrome
    David M. A. Mann · 2018 · CRC Press eBooks
47. Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer’s Disease
    Violetta N. Pivtoraiko, Tamara Racic, Eric E. Abrahamson, Victor L. Villemagne, Benjamin L. Handen, Ira T. Lott, Elizabeth Head, Miloš D. Ikonomović · 2021 · Frontiers in Aging Neuroscience
48. Distinct fractional Aβ release patterns in human mononuclear phagocytes
    Juan Manuel Maler, Philipp Spitzer, Hans‐Wolfgang Klafki, Hermann Esselmann, Piotr Lewczuk, Johannes Kornhuber, Martin Herrmann i, Jens Wiltfang · 2008 · Journal of Neuroimmunology
49. Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution
    Stephan Schilling, Claus H. Wasternack, Hans‐Ulrich Demuth · 2008 · Biological Chemistry
50. Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice
    Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Spyridon Sideromenos, Stefanie Flunkert, Joerg Neddens, Åke Lignell, Manuela Prokesch, Ute Pazenboeck et al. · 2024 · Molecular Metabolism
51. Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s disease spectrum
    Soumya Mukherjee, Reid A. Coyle, Céline Dubois, Keyla A. Perez, Catriona McLean, Colin Louis Masters, Blaine Russell Roberts · 2025 · Acta Neuropathologica
52. Post‐Translational Modifications Distinguish Amyloid‐β Isoforms in Cerebral Amyloid Angiopathy and Alzheimer's Disease
    Srinivas Koutarapu, Kaleigh F. Roberts, Reid A. Coyle, Jogender Mehla, Chihiro Sato, Gregory Joseph Zipfel, Randall John Bateman, Katherine E. Schwetye, Soumya Mukherjee · 2025 · Journal of Neurochemistry
53. One or more β-amyloid(s)? New insights into the prion-like nature of Alzheimer's disease
    Marcella Catania, Giuseppe Di Fede · 2020 · Progress in molecular biology and translational science
54. Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances
    Stefan Tholen, Maria Magdalena Koczorowska, Zon Weng Lai, Jörn Dengjel, Oliver Schilling · 2013 · Springer eBooks
55. Recombinant Production of Isotope‐Labeled Peptides and Spontaneous Cyclization of Amino‐Terminal Glutamine into Pyroglutamic Acid
    André Mischo, Oliver Ohlenschläger, Karl‐Heinz Gührs, Matthias Görlach · 2012 · ChemBioChem
56. Role of Post‐translational Chemical Modifications in Amyloid Fibril Formation
    Melanie R. Nilsson · 2005
57. Chemical Analysis of Amyloid β Protein in CAA
    Alex E. Roher, Yu‐Min Kuo, Alexander A. Roher, Mark R. Emmerling, Warren J. Goux · 2000 · Springer eBooks
58. Clinically relevant stereochemistry reprograms amyloid proteome for aggregation cross-talk–conferred neuroprotection
    Jiaxin Zhou, Juan Liu, Xilin Liu, Lixia Ren, Zhilin Yu, Zhen Zheng, Gongyu Li · 2026 · Science Advances
59. Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue
    Aram Aslanyan, Soumya Mukherjee, Eleanor M. Moncur, Alicja Szadziewska, Yingxin He, Przemysław Radosław Kac, Reid A. Coyle, Elena Camporesi, Chihiro Sato, Nupur Ghoshal et al. · 2026 · Nature Communications
60. Neurotoxicity of the Alzheimer’s β-Amyloid Peptide
    David R Howlett · 2007 · Humana Press eBooks
61. Substrate stereoselectivity of mammalian d-aspartyl endopeptidase
    Tadatoshi Kinouchi, Norihiko Fujii, Noriko Fujii · 2011 · Journal of Chromatography B
62. 3D-QSAR CoMFA Study on Human Glutaminyl Cyclase Inhibitors
    BioChem Press, Munuganti Ravi, Shashi Nayana, Yadavalli Nataraja Sekhar, Nunna Siva Kumari, Shaik Mahmood · 2007
63. Alternative pathways for production of β-amyloid peptides of Alzheimer's disease
    VIVIAN Y. H. HOOK, Israel Schechter, Hans‐Ulrich Demuth, Gregory Hook · 2008 · Biological Chemistry
64. Variable fragmentation and ionization of amyloid-beta epimers and isomers
    Elizabeth R. Readel, Umang Dhaubhadel, Arzoo Patel, Daniel W. Armstrong · 2023 · Analytical and Bioanalytical Chemistry
65. The future of dementia prevention and treatment strategies
    里 直行 · 2020 · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics
66. Microglial Responses in Alzheimer’s Disease
    Douglas G. Walker, Lih‐Fen Lue · 2003 · Humana Press eBooks
67. Post‐translational Chemical Modifications in Amyloid Fibril Formation
    Melanie R. Nilsson · 2008 · Protein Science Encyclopedia
68. Die Amyloidablagerung in einem Mausmodell der Alzheimer Demenz und die Modulation der β-Amyloid-Peptidentstehung durch membranverankerte Inhibitoren
    Heinke Schieb · 2011 · DuEPublico (University of Duisburg-Essen)
69. Optimization of anti-Abeta antibody therapy
    Rachel Karlnoski · 2007 · Digital Commons - University of South Florida (University of South Florida)
70. de dans la maladie d'Alzheimer
    Jean Sévalle · 2009
71. Isoaspartate containing amyloid precursor protein derived peptides alter efficacy and specificity of potential β-secretases
    Livia Böhme, Torsten Hoffmann, Susanne Manhart, Raik Wolf, Hans‐Ulrich Demuth · 2008 · Biological Chemistry
72. Isoaspartate residues dramatically influence substrate recognition and turnover by proteases
    Livia Böhme, Joachim Wolfgang Bär, Torsten Hoffmann, Susanne Manhart, Hans‐Henning Ludwig, Fred Rosche, Hans‐Ulrich Demuth · 2008 · Biological Chemistry
73. Post-translational modifications distinguish amyloid-β isoform patterns extracted from vascular deposits and parenchymal plaques
    Srinivas Koutarapu, Kaleigh F. Roberts, Reid A. Coyle, Jogender Mehla, Chihiro Sato, Gregory Joseph Zipfel, Randall John Bateman, Katherine E. Schwetye, Soumya Mukherjee · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
74. Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models
    Gabriella Perez, Zoe Lai, George A. Edwards, Jacob M. Dundee, Shannon N. Leahy, Chuangye Qi, Yanyan Qi, Ye-Jin Park, Tzu‐Chiao Lu, M. Danish Uddin et al. · 2026 · Molecular Neurodegeneration
75. Identification of a novel Aβ(pGlu3-x) targeting pathway in Alzheimer’s disease
    Steffen Roßner, Sarah Schrempel, Corinna Höfling, Charlotte Minister, Thomas Liepold, Marcel Naumann, Anna Katharina Kottwitz, Matti Schau, Merle Fricke, Maike Hartlage‐Rübsamen et al. · 2026 · Research Square
76. Rôle du peptide amyloïde dans les maladies neurodégénératives
    Maud Combes · 2018 · theses.fr (ABES)
77. Influences biochimiques, anatomiques et cognitives de la troncation exopeptidasique N-terminale du peptide Aβ
    Audrey Valverde · 2020 · theses.fr (ABES)
78. Enhanced Seeding Efficacy of Reverse Micelle‐Propagated Aβ 40 Oligomers Arises From Local Conformational Dynamics
    Yu-Fen Liao, Han‐Wen Chang, Wen‐Hsin Hsu, Pin-Jui Chen, Chia‐Yu Hsieh, Shing‐Jong Huang, Meng‐Hsin Wu, Ling‐Hsien Tu, Ming‐Che Lee, Hwan‐Ching Tai et al. · 2026 · Journal of the Chinese Chemical Society