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Factors influencing myofibroblast differentiation during wound healing and fibrosis.
Abstract
Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilaments bundles and the expression of α‐SM actin, the actin isoform typical of contractile vascular SM cells. Myofibroblasts have been suggested to play a role in wound contraction and in retractile phenomena observed during fibrotic diseases. When granulation tissue evolves into a scar, myofibroblasts containing α‐SM actin disappear, probably as a result of apoptosis. In contrast, myofibroblasts expressing α‐SM actin persist in excessive scarring and in fibrotic conditions. The mechanisms leading to the development of myofibroblastic features remain to be investigated. Studies on the factors regulating the phenotype of myofibroblasts will be necessary for understanding their behavior in vivo, and possibly modifying this behavior during the different clinical settings.
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Cited by
Sime, P. J., Xing, Z., Graham, F. L., Csaky, K. G., & Gauldie, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119590 · Cited by 1,050
TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
Kasai, H., Allen, J. T., Mason, R. M., Kamimura, T., & Zhang, Z. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-56 · Cited by 744
Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β 1
Zhang, H.-Y., & Phan, S. H. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.21.6.3720 · Cited by 353
Smad3 Mediates Transforming Growth Factor-β–Induced α-Smooth Muscle Actin Expression
Hu, B., Wu, Z., & Phan, S. H. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0063oc · Cited by 325
Kolodsick, J. E., Peters-Golden, M., Larios, J., Toews, G. B., Thannickal, V. J., & Moore, B. B. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0243oc · Cited by 294
Metadata
- Authors
- Desmoulière, A.
- Venue
- Cell Biology International
- Publisher
- Wiley
- Published
- 1995-05
- Volume
- 19
- Issue
- 5
- Pages
- 471-476
- ISSN
- 1065-6995 (ISSN-L)
- 1095-8355
- OpenAlex
- W2013026724
- Cited by
- 265
- References
- 0
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Desmoulière, A. (1995). Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biology International. https://doi.org/10.1006/cbir.1995.1090
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