Characterization of GDF-10 Expression Patterns and Null Mice
Open accessAbstract
Growth/differentiation factor-10 (GDF-10) is a TGF-beta family member highly related to bone morphogenetic protein-3. In order to determine the biological function of GDF-10, we carried out a detailed analysis of the expression pattern of GDF-10 and characterized GDF-10-null mice that we generated by gene targeting. During embryogenesis GDF-10 is expressed prominently in developing skeletal structures both in the craniofacial region and in the vertebral column. In adult animals, GDF-10 is expressed at high levels in the brain, where GDF-10 is localized primarily to cells in the Purkinje cell layer of the cerebellum, and in the uterus, where the expression levels of GDF-10 are regulated both during the menstrual cycle and during pregnancy. Despite the high levels of GDF-10 expression in these tissues, we found no obvious abnormalities in GDF-10-knockout mice with respect to the development of these tissues. These findings suggest either that GDF-10 plays no regulatory role in these tissues or that its function is redundant with that of other growth factor-like molecules.
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GDF10 mRNA is strongly expressed in the developing brain.
“Though GDF10 mRNA is strongly expressed in the developing brain16,17”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [17]
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References 39 · Cited by 92
- Authors
- Zhao, R., Lawler, A. M., & Lee, S.-J.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 212
- Issue
- 1
- Pages
- 68-79
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2034893482
- Cited by
- 92
- References
- 39
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- TGF-beta superfamily, knockout mice, gene targeting, embryonic skeletal development, craniofacial development, vertebral column development, cerebellum, Purkinje cells, uterus, menstrual cycle, pregnancy, expression patterns, functional redundancy
- MeSH terms
- Age Factors, Animals, Brain, Female, Genotype, Growth Substances, Immunohistochemistry, Menstrual Cycle, Models, Genetic, Placenta, Pregnancy, Pregnancy, Animal, Time Factors, Tissue Distribution, Uterus, Mice, Knockout, Gene Expression Regulation, Developmental, Bone Morphogenetic Proteins, Mice, Bone Morphogenetic Protein 3, Growth Differentiation Factor 10
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