Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions
Open accessAbstract
Different CNS regions exhibit different temporal patterns of oligodendrocyte generation and myelinogenesis. Characterization of oligodendrocyte-type-2 astrocyte progenitor cells (here abbreviated as O-2A/OPCs) isolated from different regions indicates these developmental patterns are consistent with properties of the specific O-2A/OPCs resident in each region. Marked differences were seen in self-renewal and differentiation characteristics of O-2A/OPCs isolated from cortex, optic nerve and optic chiasm. In conditions where optic nerve-derived O-2A/OPCs generated oligodendrocytes within 2 days, oligodendrocytes arose from chiasm-derived cells after 5 days and from cortical O-2A/OPCs only after 7-10 days. These differences, which appear to be cell-intrinsic (and may be related to intracellular redox state), were manifested both in reduced percentages of clones producing oligodendrocytes and in a lesser representation of oligodendrocytes in individual clones. In addition, responsiveness of optic nerve-, chiasm- and cortex-derived O-2A/OPCs to thyroid hormone (TH) and ciliary neurotrophic factor (CNTF), well-characterized inducers of oligodendrocyte generation, was inversely related to the extent of self-renewal observed in basal division conditions. Our results demonstrate hitherto unrecognized complexities among the precursor cells thought to be the immediate ancestors of oligodendrocytes, and suggest that the properties of these different populations may contribute to the diverse time courses of myelination in different CNS regions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cell-intrinsic differences in the proliferative properties of OPs from different CNS regions have been reported.
“Cell-intrinsic differences in the proliferative properties of OPs from different CNS regions have also been reported (Power et al., 2002).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Power et al., 2002
The citation lists haven’t been fetched yet
References 44 · Cited by 88
- Authors
- Power, J., Mayer-Pröschel, M., Smith, J., & Noble, M.
- Affiliations
- Columbia University (US)
- University of Rochester Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 245
- Issue
- 2
- Pages
- 362-375
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1997489128
- Cited by
- 88
- References
- 44
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 6 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 2
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- oligodendrocyte precursor cells, oligodendrocyte differentiation, myelination, optic nerve, optic chiasm, cerebral cortex, self-renewal, thyroid hormones, ciliary neurotrophic factor, redox state, central nervous system development
- MeSH terms
- Animals, Astrocytes, Brain, Cell Differentiation, Cell Division, Cerebral Cortex, Myelin Sheath, Oligodendroglia, Optic Chiasm, Optic Nerve, Oxidation-Reduction, Platelet-Derived Growth Factor, Stem Cells, Thyroid Hormones, Time Factors, Coculture Techniques, Ciliary Neurotrophic Factor, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
