The DOI matches its Crossref record; 260 of the 260 references it cites were found in a registry or an index.
Function of the c-Myc Oncogenic Transcription Factor
Open accessAbstract
The c-myc gene and the expression of the c-Myc protein are frequently altered in human cancers. The c-myc gene encodes the transcription factor c-Myc, which heterodimerizes with a partner protein, termed Max, to regulate gene expression. Max also heterodimerizes with the Mad family of proteins to repress transcription, antagonize c-Myc, and promote cellular differentiation. The constitutive activation of c-myc expression is key to the genesis of many cancers, and hence the understanding of c-Myc function depends on our understanding of its target genes. In this review, we attempt to place the putative target genes of c-Myc in the context of c-Myc-mediated phenotypes. From this perspective, c-Myc emerges as an oncogenic transcription factor that integrates the cell cycle machinery with cell adhesion, cellular metabolism, and the apoptotic pathways.
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Cites
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Cited by
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Metadata
- Authors
- Dang, C. V., Resar, L. M. S., Emison, E., Kim, S., Li, Q., Prescott, J. E., Wonsey, D., & Zeller, K.
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 253
- Issue
- 1
- Pages
- 63-77
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W2069506641
- Cited by
- 379
- References
- 260
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dang, C. V., Resar, L. M. S., Emison, E., Kim, S., Li, Q., Prescott, J. E., Wonsey, D., & Zeller, K. (1999). Function of the c-Myc Oncogenic Transcription Factor. Experimental Cell Research. https://doi.org/10.1006/excr.1999.4686
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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