The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Early Amyloid Deposition in the Medial Temporal Lobe of Young Down Syndrome Patients: A Regional Quantitative Analysis
Abstract
The presence of the neuropathological alterations of Alzheimer's disease (AD) in essentially all older Down syndrome (DS) patients suggests that the examination of younger DS patients may clarify the early pathological progression of AD. We examined the hippocampus and parahippocampal-inferior temporal gyri of 42 DS patients (ages 4 days to 38 years) for the deposition of amyloid beta protein (Abeta) using both a modified Bielschowsky stain and immunohistochemistry for Abeta protein. The parahippocampal and inferior temporal gyri demonstrated Abeta staining in cases as young as 8 years of age. As age and degree of Abeta deposition increased, staining included the CA-1/subiculum and dentate molecular layer followed then by the remainder of the CA hippocampal regions. The first neuritic plaques were observed in the CA-1/subiculum, despite this being a later region of Abeta deposition. Although Abeta staining increased with age, there was substantial variability in the severity of Abeta deposition within age groups. These results suggest that within the hippocampal/parahippocampal region there is a progressive stereotypic deposition of Abeta. The variable severity of Abeta deposition within age groups suggests that other factors, besides DS, may be contributing to the timing and severity of Abeta deposition.
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“Individuals with Down syndrome (DS), caused by trisomy of chromosome 21 (chr21, T21), are strongly predisposed to Alzheimer’s disease (AD), due to triplication of the APP gene, with ∼100% penetrance of AD brain pathology by age 40 and variable onset of dementia thereafter.”
From Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model (2025) · cites this paper as [8]
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Cites
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1 of the 33 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Bertrand, 1946, Cas d'idiotic mongolienne adulte avec nombreuses plaques seniles et concretions calcaires pallidales, Rev. Neurol. (Paris), 78, 338
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Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
Braak, H., Thal, D. R., Ghebremedhin, E., & Del Tredici, K. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318232a379 · Cited by 2,194
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L. J., Fisher, E. M. C., & Strydom, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3983 · Cited by 562
Cognitive deficits and associated neurological complications in individuals with Down's syndrome
Lott, I. T., & Dierssen, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70112-5 · Cited by 484
Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy
Zheng, Q., & Wang, X. (2024) · Protein & Cell · doi:10.1093/procel/pwae026 · Cited by 483
Metadata
- Authors
- Leverenz, J. B., & Raskind, M. A.
- Affiliations
- University of Washington (US)
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 150
- Issue
- 2
- Pages
- 296-304
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1994573232
- Cited by
- 214
- References
- 33
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 4 · 2015: 15 · 2014: 17 · 2013: 7 · 2012: 9
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AGE-WELL
- Ministerul Cercetării, Inovării şi Digitalizării
- National Institute on Aging (AG 05136, AG00503, P50AG005136)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Down syndrome, amyloid-beta deposition, Alzheimer's disease, medial temporal lobe, hippocampus, parahippocampal gyrus, inferior temporal gyrus, neuritic plaques
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aging, Alzheimer Disease, Child, Child, Preschool, Down Syndrome, Female, Hippocampus, Humans, Immunohistochemistry, Infant, Infant, Newborn, Male, Organ Specificity, Reference Values, Regression Analysis, Temporal Lobe, Amyloid beta-Peptides
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