The DOI matches its Crossref record.
Biopersistence of Man-Made Vitreous Fibers and Crocidolite Asbestos in the Rat Lung Following Inhalation
Abstract
This study investigated possible relationships between fiber bio-persistence in the lung and previously observed differences in pulmonary toxicity between asbestos and man-made vitreous fibers (MMVF) following inhalation exposure. Fischer 344/N rats were exposed nose only, 6 hr/day for 5 days to 30 mg/m3 MMVF (two fiberglass compositions, rock wool, or slag wool) or to 10 mg/m3 crocidolite asbestos. At eight time points up to 1 year postexposure, lung fiber burdens were analyzed for number/lung and bivariate dimensions using scanning electron microscopy (SEM) and for chemical composition using SEM energy dispersive spectroscopy. After 365 days, > 95% of long (> 20 microns) MMVFs had disappeared from the lung compared to only 17% of long crocidolite fibers. Longer MMVFs disappeared more rapidly than short MMVFs, suggesting that long fibers were dissolving or breaking. Mean diameters and lengths of the MMVFs decreased with time, while the mean diameter of crocidolite remained unchanged and its mean length showed an apparent increase, probably related to macrophage-mediated clearance of short fibers. Leaching of oxides occurred in the fibrous glasses and slag wool and correlated with morphological changes in the fibers over time. No chemical or morphological changes were observed in crocidolite fibers. These changes in MMVF number, chemistry, and morphology over time in lung tissue compared to crocidolite asbestos demonstrate the relatively low biological persistence of some MMV…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In conclusion, the analysis of 5 publications related to nose-only exposure of amphiboles in rats, demonstrated a lower biopersistence of SAF than LAF [102,112-114,116], in agreement with other results using long-term inhalation exposure.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [114]
In the citing paper
“Studies conducted with crocidolite fibers showed a lower retention of fibers < 5 μm compared to fibers > 5 μm or > 20 μm [112,113] or to WHO fibers [114].”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [114]
Citations
Cited by
Sorted by citations
Donaldson, K., Murphy, F. A., Duffin, R., & Poland, C. A. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-5 · Cited by 916
Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Bernstein, D., Castranova, V., Donaldson, K., Fubini, B., Hadley, J., Hesterberg, T., Kane, A., Lai, D., McConnell, E. E., Muhle, H., et al. (2005) · Inhalation Toxicology · doi:10.1080/08958370591001121 · Cited by 103
Self-citationBernstein, D. M., Rogers, R. A., Sepulveda, R., Kunzendorf, P., Bellmann, B., Ernst, H., Creutzenberg, O., & Phillips, J. I. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.12.012 · Cited by 36
Pacella, A., Fantauzzi, M., Turci, F., Cremisini, C., Montereali, M. R., Nardi, E., Atzei, D., Rossi, A., & Andreozzi, G. B. (2015) · Chemical Geology · doi:10.1016/j.chemgeo.2015.03.028 · Cited by 31
Mesothelial Cell Proliferation and Biopersistence of Wollastonite and Crocidolite Asbestos Fibers
Macdonald, J. (1997) · Fundamental and Applied Toxicology · doi:10.1006/faat.1997.2344 · Cited by 19
Metadata
- Authors
- Hesterberg, T.
- Venue
- Fundamental and Applied Toxicology
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 29
- Issue
- 2
- Pages
- 267-279
- ISSN
- 0272-0590
- Cited by
- 58
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
