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DNA Sequence and Analysis of 136 Kilobases of the Escherichia coli Genome: Organizational Symmetry around the Origin of Replication
Abstract
The DNA sequence of a 136-kb segment (81.5 to 84.5 min) from the Escherichia coli origin of replication region has been determined and analyzed. Of the 122 protein coding regions that were found, we could assign no gene name or function to half of them, even in this well-studied part of the genome. The newly sequenced region also includes five RNA genes. The arrangement of open reading frames and potential promoters suggests 63 transcription units. The sequence was also analyzed for bend sites and two types of repeated sequence elements. Together with our sequence of the 84.5 to 86.5 min region, this new determination forms a 227-kb contiguous region centered on oriC. A global analysis of this region reveals a remarkable symmetry: most genes are transcribed divergently from the replication origin, and Chi octanucleotide (5'GCTGGTGG3') recombinational hot spots are also strikingly oriented with respect to the directions of replication and translation.
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Citations
Cited by
Kogoma, T. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.2.212-238.1997 · Cited by 532
Collapse and repair of replication forks in Escherichia coli
Kuzminov, A. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02403.x · Cited by 364
Twenty years of bacterial genome sequencing
Loman, N. J., & Pallen, M. J. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3565 · Cited by 344
Multidrug resistance pumps in bacteria: variations on a theme
Lewis, K. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90204-6 · Cited by 306
Membrane Topology of the 60-kDa Oxa1p Homologue fromEscherichia coli
Sääf, A., Monné, M., de Gier, J.-W., & von Heijne, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30415 · Cited by 89
Metadata
- Authors
- Burland, V., Plunkett, G., Daniels, D. L., & Blattner, F. R.
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 16
- Issue
- 3
- Pages
- 551-561
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W2143420721
- Cited by
- 211
- References
- 0
- FWCI
- 18.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DNA Sequence and Analysis of 136 Kilobases of the Escherichia coli Genome: Organizational Symmetry around the Origin of Replication. https://app.cochat.ai/papers/10.1006/geno.1993.1230
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- Burland, V., Plunkett, G., Daniels, D. L., & Blattner, F. R. (1993). DNA Sequence and Analysis of 136 Kilobases of the Escherichia coli Genome: Organizational Symmetry around the Origin of Replication. Genomics. https://doi.org/10.1006/geno.1993.1230
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