Mapping the Gene That Encodes Phosphatidylinositol-Specific Phospholipase C-γ2 in the Human and the Mouse
Abstract
We have mapped the PLCG2 gene, which encodes the enzyme phosphatidyl inositol-specific phospholipase C-gamma 2. This is one of the phospholipases responsible for catalyzing the hydrolysis of phosphatidyl inositol in response to a great many mitogenic stimuli. PL C-gamma 2 is an essential component of the signal transduction pathway between tyrosine kinases and downstream events such as protein kinase C activation and intracellular calcium release. We assigned PLCG2 to human chromosome 16 by amplification within a somatic cell hybrid mapping panel. To position the locus at a much finer resolution, PLCG2 sequences were amplified from a chromosome 16-specific somatic cell hybrid panel, which placed the gene on the long arm of the chromosome in band 16q24.1, a region that has few known genes. We have hybridized a mouse Plcg2 open reading frame probe to mouse DNAs from the European Interspecific Backcross. The segregation pattern reveals the mouse Plcg2 locus maps to distal chromosome 8.
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PLCG2 is a membrane-associated enzyme that catalyzes the conversion of PIP2 to IP3 and DAG, which plays a crucial role in cell-surface receptor signal transduction.
“PLCG2 is a membrane-associated enzyme that catalyzes the conversion of phospholipid PIP2 (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) to IP3 (1D-myo-inositol 1,4,5-trisphosphate) and DAG (diacylglycerol), which plays a crucial role in cell-surface receptor signal transduction [12].”
From PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease (2022) · cites this paper as [12]
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The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
Jackson, J. T., Mulazzani, E., Nutt, S. L., & Masters, S. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100905 · Cited by 113 · see citing works
“immunological and growth factor receptors (1, 2), including activation of PKC and intracellular calcium release (2, 3).”
BackgroundTsai, A. P., Dong, C., Lin, P. B.-C., Messenger, E. J., Casali, B. T., Moutinho, M., Liu, Y., Oblak, A. L., Lamb, B. T., Landreth, G. E., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01022-0 · Cited by 92 · see citing works
Oblak, A. L., Kotredes, K. P., Pandey, R. S., Reagan, A. M., Ingraham, C., Perkins, B., Lloyd, C., Baker, D., Lin, P. B., Soni, D. M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.886575 · Cited by 23 · see citing works
“PLCG2 plays a crucial role in signal transduction between tyrosine kinases and downstream events, protein kinase C activation, and intracellular calcium release (Hernandez et al., 1994).”
Background
- Authors
- Hernandez, D., Egan, S. E., Yulug, I. G., & Fisher, E. M. C.
- Affiliations
- Hospital for Sick Children (CA)
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 23
- Issue
- 2
- Pages
- 504-507
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W2061236317
- Cited by
- 22
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2015: 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- PLCγ2, gene mapping, human chromosome 16, mouse chromosome 8, somatic cell hybrid mapping, interspecific backcross, signal transduction, protein kinase C activation, intracellular calcium release, mitogen stimulation
- MeSH terms
- Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 16, Crosses, Genetic, Female, Humans, Hybrid Cells, Male, Mice, Inbred C57BL, Molecular Sequence Data, Muridae, Phosphoric Diester Hydrolases, DNA Primers, DNA, Complementary, Phosphatidylinositol Diacylglycerol-Lyase, Mice, Phosphoinositide Phospholipase C
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