Genomic Organization and Chromosomal Localization of the HumanSGKProtein Kinase Gene
Abstract
The SGK protein kinase is a novel member of the serine/threonine protein kinase family. Its corresponding gene belongs to the group of immediate-early genes. SGK transcription is controlled by cell volume alterations in different cell lines. To analyze the genomic structure and chromosomal location of the SGK gene, a human P1 clone was isolated by screening a human genomic library with a SGK cDNA probe. This clone was confirmed to encode the authentic SGK gene by the detection of exon-intron structures and the correspondence between the nucleotide sequences of exons and human cDNA. Using this P1 clone as a probe for fluorescence in situ hybridization, a single chromosomal locus for SGK was assigned to band 6q23, a region frequently affected by deletion in various human neoplasms.
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The human SGK1 gene is located on chromosome 6 at 6q23, spans 148,867 bases, contains 14 coding exons, and encodes a 431-amino-acid protein of approximately 49 kDa.
“The SGK1 gene in the human genome is located on chromosome 6 at the 6q23 region, spans 148,867 bases, and contains 14 coding exons. It encodes the SGK1 protein, which comprises 431 amino acids and has a molecular mass of approximately 49 kDa”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Waldegger et al., 1998
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(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms
Lang, F., Böhmer, C., Palmada, M., Seebohm, G., Strutz-Seebohm, N., & Vallon, V. (2006) · Physiological Reviews · doi:10.1152/physrev.00050.2005 · Cited by 689 · see citing works
Self-citationChen, B.-Y., Huang, C.-C., Lv, X.-F., Zheng, H.-Q., Zhang, Y.-J., Sun, L., Wang, G.-L., Ma, M.-M., & Guan, Y.-Y. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0357-y · Cited by 18 · see citing works
Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain
Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13 · see citing works
- Authors
- Waldegger, S., Erdel, M., Nagl, U. O., Barth, P., Raber, G., Steuer, S., Utermann, G., Paulmichl, M., & Lang, F.
- Affiliations
- University of Tübingen (DE)
- Universität Innsbruck (AT)
- Corresponding author
- Waldegger, Siegfried
- ORCID
- Erdel, Martin
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 51
- Issue
- 2
- Pages
- 299-302
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W145391499
- Cited by
- 45
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2017: 2 · 2016: 3 · 2014: 1
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- genome organization, chromosomal localization, exon-intron structure, immediate early genes, serine/threonine kinase, cell volume regulation, fluorescence in situ hybridization, gene mapping
- MeSH terms
- Serum-Glucocorticoid Regulated Kinases, Cell Line, Chromosomes, Human, Pair 6, Cloning, Molecular, Genes, Humans, Male, Molecular Sequence Data, Nuclear Proteins, Restriction Mapping, Protein Serine-Threonine Kinases, Sequence Analysis, DNA, Immediate-Early Proteins, Gene Dosage, Physical Chromosome Mapping
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