Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain
Abstract
Rat striatin, a recently discovered calmodulin-binding protein belonging to the WD repeat family, is expressed in neurons, mostly in the striatum and motor and olfactory systems. Striatin is localized in the somato-dendritic compartment of neurons, mainly in the spines. It may play a role in dendritic Ca2+ signaling. Here we report the cloning and sequencing of human striatin cDNA (HGMW-approved symbol STRN), the localization of the gene to chromosome 2p22-p21, and its preferential expression in brain. The human cDNA sequence is predicted to encode a 780-amino-acid protein possessing eight WD repeats. Striatin is highly conserved between rat and human with 96% identity and 98% similarity at the amino acid level. Since the Caenorabditis elegans genome also contains a closely related striatin coding sequence, the function of striatin is likely to be well conserved.
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The B′′′ family consists of Striatin, Striatin-3, and Striatin-4, which localize mainly to dendritic spines of the corpus striatum.
“The B”’ family of regulatory subunits is comprised of 3 members: Striatin, Striatin-3 (also known as SG2NA), and Striatin-4 (also known as Zinedin). They are localized primarily in dendritic spines of the corpus striatum, which is an essential component of the motor system (Castets et al., 1996; Moqrich et al., 1998; Salin et al., 1998).”
From PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer (2019) · cites this paper as Moqrich et al., 1998
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References 10 · Cited by 32
- Authors
- Moqrich, A., Mattei, M. G., Bartoli, M., Rakitina, T., Baillat, G., Monneron, A., & Castets, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Castets, F.
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 51
- Issue
- 1
- Pages
- 136-139
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W1995405433
- Cited by
- 32
- References
- 10
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- striatin, cDNA cloning, gene mapping, WD-repeat proteins, calmodulin-binding proteins, brain expression, striatum, dendritic calcium signaling
- MeSH terms
- Amino Acid Sequence, Animals, Calmodulin-Binding Proteins, Central Nervous System, Chromosome Mapping, Chromosomes, Human, Pair 2, Cloning, Molecular, Corpus Striatum, Humans, Membrane Proteins, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Tissue Distribution, Sequence Homology, Amino Acid, In Situ Hybridization, Fluorescence, DNA, Complementary, Rats
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