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Metabolic Rate, Generation Time, and the Rate of Molecular Evolution in Birds
Abstract
A recent hypothesis suggests that resting metabolic rate, measured as energy expended per unit body mass per unit time, might be implicated in the rate of nucleotide substitution in animals. Using relative rate tests on DNA-DNA hybridization data from birds, we show that generation time is significantly correlated with genetic distance between members of an ingroup and an outgroup taxon, but that neither metabolic rate nor body mass explain variation consistent with the hypothesis, either alone or with generation time.
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“The predicted correlation of generation time with mutation rate 24 has been supported by studies that compare the rates of molecular evolution with generation time (or its correlate, body size) across a range of genes for several vertebrate species 35,37-39 .”
From The modern molecular clock (2003) · cites this paper as [39]
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Species–energy relationships at the macroecological scale: a review of the mechanisms
Evans, K. L., Warren, P. H., & Gaston, K. J. (2005) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793104006517 · Cited by 768
“Genetic distances of species pairs, measured relative to an outgroup, by either the relative rates test or DNA hybridisation distances, should thus be greater in species occupying high-energy areas (Li & Graur, 1991; Mooers & Harvey, 1994; Bromham & Cardillo, 2003).”
BackgroundRates of Molecular Evolution Are Linked to Life History in Flowering Plants
Smith, S. A., & Donoghue, M. J. (2008) · Science · doi:10.1126/science.1163197 · Cited by 757
Bromham, L., & Penny, D. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1020 · Cited by 615
“This is consistent with the observations that ECTOTHERMS have lower substitution rates than ENDOTHERMS 36, that smaller-bodied species of vertebrates with faster metabolic rates have higher substitution rates than larger-bodied specie”
ResultLIVEZEY, B. C., & ZUSI, R. L. (2007) · Zoological Journal of the Linnean Society · doi:10.1111/j.1096-3642.2006.00293.x · Cited by 574
Strong Variations of Mitochondrial Mutation Rate across Mammals--the Longevity Hypothesis
Nabholz, B., Glémin, S., & Galtier, N. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm248 · Cited by 482
“The generation time hypothesis (Li et al. 1987; Ohta 1993; Mooers and Harvey 1994; Bromham et al. 1996) expresses that species with a shorter generation time experience a higher number of DNA replication rounds per year and thus a higher number of replication errors per time unit.”
Background
Metadata
- Authors
- Mooers, A. Ø., & Harvey, P. H.
- Affiliations
- University of Oxford (GB)
- Venue
- Molecular Phylogenetics and Evolution
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 3
- Issue
- 4
- Pages
- 344-350
- ISSN
- 1055-7903 (ISSN-L)
- OpenAlex
- W1972334286
- Cited by
- 141
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 8 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 4
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Phylogenetics and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- resting metabolic rate, generation time, molecular evolution rate, nucleotide substitution rates, birds, genetic distance, DNA-DNA hybridization, body mass, relative rate tests, phylogenetic distance
- MeSH terms
- Age Factors, Animals, Basal Metabolism, Base Sequence, Biological Clocks, Birds, Body Temperature Regulation, Energy Metabolism, Mutation, Reproduction, Species Specificity
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