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Cited by 44Immunotherapy and Immune ResponsesVirus-based gene therapy researchBacterial Cancer Therapy

The DOI matches its Crossref record; 45 of the 49 references it cites were found in a registry or an index.

Gene Therapy for Head and Neck Cancer Using Vaccinia Virus Expressing IL-2 in a Murine Model, with Evidence of Immune Suppression

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Qin, Hongxing, Valentino, Joseph, Manna, Subha, Tripathi, Pulak K., Bhattacharya-Chatterjee, Malaya, Foon, Kenneth A., O'Malley, Bert W., Chatterjee, Sunil K.·2001·Molecular Therapy
DOI 10.1006/mthe.2001.0493
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Abstract

We evaluated the efficiency of recombinant vaccinia virus expressing interleukin-2 (rvv-IL-2) as a tumor vaccine in an immunocompetent mouse model of head and neck squamous cell carcinoma (SCC VII/SF). Mice with five-day-old tumors in the floor of the mouth were treated with rvv-IL-2 by intratumoral injections. These treated mice survived longer (P <.03) than mice treated with control vaccines. Splenocytes, bone marrow, and lymph node cells from tumor-bearing mice responded poorly to concanavalin A stimulation, suggesting induction of immunosuppression. The rvv-IL-2 virus grew for 7 days in the tumor following intratumoral injection. We did not detect any virus particles in several normal organs following rvv-IL-2 injection. Comparison of expression levels of several potential immune inhibitory mediators between the tumors growing in mice and cultured tumor cells demonstrated higher expression of IL-10, GM-CSF, TGF-beta, and NO synthetase in tumors. These results suggested possible roles for these molecules in immunosuppression. We conclude that rvv-IL-2 has potential as a therapeutic vaccine for head and neck cancer and that it can be more effective provided the immunosuppression is reversed.

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Crossref · 10.1006/mthe.2001.0493

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Research works printed but not linked: 1

  1. Lattime, 1997, Gene therapy using intratumoral (IT) recombinant GM-CSF encoding vaccinia virus in patients with melanoma, Proc. Am. Assoc. Cancer Res., 38, 11

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Metadata

Authors
Qin, H., Valentino, J., Manna, S., Tripathi, P. K., Bhattacharya-Chatterjee, M., Foon, K. A., O'Malley, B. W., & Chatterjee, S. K.
Affiliations
  • University of Cincinnati (US)
  • University of Kentucky (US)
  • University of Maryland, Baltimore (US)
Corresponding author
Chatterjee, Sunil K.
ORCID
Venue
Molecular Therapy
Publisher
Elsevier BV
Published
2001-12
Volume
4
Issue
6
Pages
551-558
ISSN
1525-0016 (ISSN-L)
DOI
10.1006/mthe.2001.0493
OpenAlex
W1980802790
Cited by
44
References
49
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
1.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Therapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ca089748-04)
  • National Cancer Institute (CA 89748)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords
gene therapy, head and neck squamous cell carcinoma, vaccinia virus, interleukin-2, cancer vaccines, immunosuppression, intratumoral injection, IL-10, GM-CSF, TGF-beta, nitric oxide synthase, tumor immunology, mouse tumor model
MeSH terms
Animals, Bone Marrow, Carcinoma, Squamous Cell, Concanavalin A, Genetic Vectors, Head and Neck Neoplasms, Humans, Immunosuppression Therapy, Interleukin-2, Lymph Nodes, Neoplasm Transplantation, Spleen, T-Lymphocytes, Vaccinia virus, Genetic Therapy, Survival Rate, Granulocyte-Macrophage Colony-Stimulating Factor, Transforming Growth Factor beta, Interleukin-10, DNA Primers, Nitric Oxide Synthase, Reverse Transcriptase Polymerase Chain Reaction, Mice

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