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Striatal fosB Expression Is Causally Linked with l-DOPA-Induced Abnormal Involuntary Movements and the Associated Upregulation of Striatal Prodynorphin mRNA in a Rat Model of Parkinson's Disease
Open accessAbstract
Rats with unilateral dopamine-denervating lesions sustained a 3-week treatment with a daily l-DOPA dose that is in the therapeutic range for Parkinson's disease. In most of the treated animals, chronic l-DOPA administration gradually induced abnormal involuntary movements affecting cranial, trunk, and limb muscles on the side of the body contralateral to the lesion. This effect was paralleled by an induction of FosB-like immunoreactive proteins in striatal subregions somatotopically related to the types of movements that had been elicited by l-DOPA. The induced proteins showed both regional and cellular colocalization with prodynorphin mRNA. Intrastriatal infusion of fosB antisense inhibited the development of dyskinetic movements that were related to the striatal subregion targeted and produced a local specific downregulation of prodynorphin mRNA. These data provide compelling evidence of a causal role for striatal fosB induction in the development of l-DOPA-induced dyskinesia in the rat and of a positive regulation of prodynorphin gene expression by FosB-related transcription factors.
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Cites
Experimental Design: Procedures for the Behavioral Sciences
Kirk, R. (2013) · doi:10.4135/9781483384733 · Cited by 8,539
Cited by
Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
Picconi, B., Centonze, D., Håkansson, K., Bernardi, G., Greengard, P., Fisone, G., Cenci, M. A., & Calabresi, P. (2003) · Nature Neuroscience · doi:10.1038/nn1040 · Cited by 821
Self-citationLundblad, M., Andersson, M., Winkler, C., Kirik, D., Wierup, N., & Cenci, M. A. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01843.x · Cited by 664
Self-citationSantini, E., Valjent, E., Usiello, A., Carta, M., Borgkvist, A., Girault, J.-A., Herve, D., Greengard, P., & Fisone, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0852-07.2007 · Cited by 437
ΔFosB: a molecular switch for long-term adaptation in the brain
McClung, C. A., Ulery, P. G., Perrotti, L. I., Zachariou, V., Berton, O., & Nestler, E. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.014 · Cited by 398
Westin, J. E., Vercammen, L., Strome, E. M., Konradi, C., & Cenci, M. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.032 · Cited by 277
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Metadata
- Authors
- Andersson, M., Hilbertson, A., & Cenci, M. A.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 6
- Issue
- 6
- Pages
- 461-474
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2078747341
- Cited by
- 350
- References
- 1
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Andersson, M., Hilbertson, A., & Cenci, M. A. (1999). Striatal fosB Expression Is Causally Linked with l-DOPA-Induced Abnormal Involuntary Movements and the Associated Upregulation of Striatal Prodynorphin mRNA in a Rat Model of Parkinson's Disease. Neurobiology of Disease. https://doi.org/10.1006/nbdi.1999.0259
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