Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome
Open accessAbstract
The processes involved with beta-amyloid (Abeta) degradation and clearance in human brain are not well understood. We hypothesized that the distribution of oxidatively modified Abeta, as determined by an affinity-purified antibody in the entorhinal and frontal cortices of Alzheimer's disease (AD), Down syndrome (DS), nondemented elderly control cases, and canine brain, would provide insight into the mechanisms of Abeta accumulation. Based upon plaque counts, oxidized Abeta was present within 46-48% of diffuse and primitive plaques and 98% of cored plaques. Dense punctate deposits of oxidized Abeta were distributed throughout the neuropil in AD and DS brains but were also present within controls with mild neuropathology and isolated cognitive impairments. Confocal studies indicate that punctate oxidized Abeta deposits were within activated microglia. Oxidatively modified Abeta may reflect the efforts of microglial cells to take up and degrade Abeta. Oxidative modification of Abeta may be an early event in Abeta pathogenesis and may be important for plaque biogenesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Analysis confirmed occurrence of glycation end products and process of glycoxidation triggered very early in prenatal life.
“The analysis confirmed the occurrence of glycation end products and that the process of glycoxidation is triggered very early in prenatal life (Head et al. 2001).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Head et al. 2001
The citation lists haven’t been fetched yet
References 77 · Cited by 75
- Authors
- Head, E., Garzon-Rodriguez, W., Johnson, J. K., Lott, I. T., Cotman, C. W., & Glabe, C.
- Affiliations
- University of California, Irvine (US)
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 8
- Issue
- 5
- Pages
- 792-806
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2006173276
- Cited by
- 75
- References
- 77
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (AG00538, AG12694, AG16573)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, Down syndrome, amyloid plaques, microglia, amyloid clearance, entorhinal cortex, frontal cortex, oxidative modification, diffuse plaques
- MeSH terms
- Alzheimer Disease, Brain, Down Syndrome, HLA-DR Antigens, Humans, Oxidation-Reduction, Amyloid beta-Peptides, Microglia, Microscopy, Confocal, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
