The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Dendritic Spine Hypoplasticity and Downregulation of Reelin and GABAergic Tone in Schizophrenia Vulnerability
Open accessAbstract
In this review, we will first present a brief overview of the current understanding of: (a) the biology of reelin; (b) the putative reelin signaling pathways via integrin receptor stimulation; (c) the cytosolic adapter protein DAB1, which appears to be operative in the transduction of reelin's pleiotropic actions in embryonic, adolescent, and adult brain; (d) the regulation of GABAergic function, including some aspects of GABAergic system development; and (e) dendritic spine function and its role in the regulation of synaptic plasticity. We argue that a downregulation of reelin expression occurring in prefrontal cortex and in every brain structure of schizophrenia patients so far studied may be associated with a decrease in dendritic spine expression that in turn may provide an important reduction of cortical function as documented by the downregulation of glutamic acid decarboxylase67 (GAD67) expression, which might be secondary to a reduction of GABAergic axon terminals. This hypothesis is supported by a genetic mouse model of reelin haploinsufficiency that replicates the above-described dendritic and presynaptic GABAergic defects documented in schizophrenia brains.
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Cited by
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
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Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
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Regulation of affect by the lateral septum: implications for neuropsychiatry
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Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
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Dysregulation of the fibroblast growth factor system in major depression
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Metadata
- Authors
- Costa, E., Davis, J., Grayson, D. R., Guidotti, A., Pappas, G. D., & Pesold, C.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 8
- Issue
- 5
- Pages
- 723-742
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2026696795
- Cited by
- 195
- References
- 21
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Costa, E., Davis, J., Grayson, D. R., Guidotti, A., Pappas, G. D., & Pesold, C. (2001). Dendritic Spine Hypoplasticity and Downregulation of Reelin and GABAergic Tone in Schizophrenia Vulnerability. Neurobiology of Disease. https://doi.org/10.1006/nbdi.2001.0436
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