The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Diffusion Tensor Imaging and Axonal Tracking in the Human Brainstem
Abstract
Diffusion tensor MRI was used to demonstrate in vivo anatomical mapping of brainstem axonal connections. It was possible to identify the corticospinal tract (CST), medial lemniscus, and the superior, medial, and inferior cerebellar peduncles. In addition, the cerebral peduncle could be subparcellated into component tracts, namely, the frontopontine tract, the CST, and the temporo-/parieto-/occipitopontine tract. Anatomical landmarks and tracking thresholds were established for each fiber and, using these standards, reproducibility of automated tracking as assessed by intra- and interrater reliability was found to be high (kappa > 0.82). Reconstructed fibers corresponded well to existing anatomical knowledge, validating the tracking. Information on the location of individual tracts was coregistered with quantitative MRI maps to automatically measure MRI parameters on a tract-by-tract basis. The results reveal that each tract has a unique spatial signature in terms of water relaxation and diffusion anisotropy.
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“Pathways traced in this way are reproducible (Heiervang et al. 2006) and generally reproduce those identified using postmortem dissection or tract tracing (Stieltjes et al. 2001; Croxson et al. 2005).”
From Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression (2008) · cites this paper as Stieltjes et al. 2001
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1 of the 31 references couldn’t be matched to a known paper.
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Self-citation
Metadata
- Authors
- Stieltjes, B., Kaufmann, W. E., van Zijl, P. C. M., Fredericksen, K., Pearlson, G. D., Solaiyappan, M., & Mori, S.
- Affiliations
- Johns Hopkins University (US)
- Kennedy Krieger Institute (US)
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 14
- Issue
- 3
- Pages
- 723-735
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2156715960
- Cited by
- 492
- References
- 31
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 14 · 2016: 13 · 2015: 23 · 2014: 22 · 2013: 26 · 2012: 18
- FWCI
- 20.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r03ag016028-01)
- National Institute on Aging (AG016028)
- National Institute of Mental Health (MH 52886, R01MH052886)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015909)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37931, R03HD037931, HD24061, P30HD024061)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- brainstem, corticospinal tract, medial lemniscus, cerebellar peduncles, cerebral peduncle, tractography, diffusion anisotropy, water relaxation
- MeSH terms
- Adult, Axons, Brain Mapping, Brain Stem, Color, Differential Threshold, Female, Humans, Magnetic Resonance Imaging, Male, Anisotropy
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