CoChat
Sign Up
Cited by 231Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

The DOI matches its Crossref record.

Correlation between the Pharmacology of Long-Term Potentiation and the Pharmacology of Memory

Izquierdo, I., Medina, J.H.·1995·Neurobiology of Learning and Memory
DOI 10.1006/nlme.1995.1002
Open this paper in CoChat — free account

Abstract

The pharmacology of memory has been recently studied by the infusion of drugs into the hippocampus (HIP), amygdala (AMY), medial septum (MS), and entorhinal cortex (EC) at various times after training or at the time of retention testing. It was found to be remarkably similar to that of long-term potentiation (LTP). Memory and LTP are blocked early on by antagonists of glutamate N-methyl-D-aspartate (NMDA) or metabotropic receptors (mGLUs), by the antagonist of the presynaptic membrane receptor to PAF, BN 52021, by the inhibitor of heme oxygenase, ZnPP, by the inhibitor of NO synthase, N-nitro-arginine, by GABA type A receptor agonists, or by muscarinic blockers. Both memory and LTP are enhanced, at this early stage, by glutamate, mGLU agonists, GABA-A antagonists, muscarinic agonists, and norepinephrine. In the next 1-3 h, memory and LTP are accompanied by enhanced activity of protein kinases and are blocked by specific inhibitors of calcium/calmodulin dependent protein kinase II and protein kinase C. At the time of expression, memory and LTP are blocked by antagonists of glutamate AMPA receptors and are accompanied by an enhanced sensitivity of these receptors. Memories that depend on HIP are affected by drugs given into the HIP but not the MS or AMY, memories that depend on the AMY are affected by drugs given into the AMY, and memories that depend on the HIP, AMY, and MS are affected by drugs given into the three structures.(ABSTRACT TRUNCATED AT 250 WORDS)

Overview

Integrity signals

Registry

Crossref · 10.1006/nlme.1995.1002

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Items 201–231 of 231

Related

See all

Metadata

Authors
Izquierdo, I., & Medina, J. H.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
ORCID
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
1995-01
Volume
63
Issue
1
Pages
19-32
ISSN
1074-7427 (ISSN-L)
DOI
10.1006/nlme.1995.1002
OpenAlex
W2046474139
Cited by
230
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
7.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
long-term potentiation, hippocampus, amygdala, medial septum, entorhinal cortex, NMDA receptor antagonists, metabotropic glutamate receptors, PAF receptor antagonists, heme oxygenase inhibition, nitric oxide synthase inhibition, GABAA receptor, muscarinic receptors, norepinephrine, protein kinases, calcium/calmodulin-dependent protein kinase II, protein kinase C, AMPA receptors, memory expression, memory consolidation
MeSH terms
Amygdala, Animals, Brain, Brain Mapping, Hippocampus, Memory, Septum Pellucidum, Neurotransmitter Uptake Inhibitors, Long-Term Potentiation, Receptors, Neurotransmitter, Neurotransmitter Agents, Entorhinal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review