Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats
Abstract
The anti-inflammatory effect of c-phycocyanin extract was studied in acetic acid-induced colitis in rats. Phycocyanin (150, 200 and 300 mg kg-1 p.o.) was administered 30 min before induction of colitis with enema of 1 ml of 4% acetic acid per rat. Twenty-four hours later myeloperoxidase (MPO) activity was determined as well as histopathological and ultrastructural studies were carried out in colonic tissue. Phycocyanin substantially reduced MPO activity which was increased in the control colitis group. Also, histopathological and ultrastructural studies showed inhibition in inflammatory cell infiltration and reduction to some extent in colonic damage in rats treated with phycocyanin. The probable role of antioxidative and the scavenging properties of phycocyanin against reactive oxygen species in the anti-colitic effect is discussed in this paper. To our knowledge this is the first report on the anti-inflammatory effect of phycocyanin in an experimental model of colitis.(c) 1999 The Italian Pharmacological Society.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
C-phycocyanin strongly inhibits inflammation in macrophages and animal models.
“In particular, C-PC, a natural blue pigment (~14% of SP dry weight) [40, 43, 44], has shown to have a strong inhibitory property against inflammation in macrophages [45, 46] and in animal models [47, 48].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [48]
The citation lists haven’t been fetched yet
References 16 · Cited by 220
- Authors
- GONZÁLEZ, R., RODRÍGUEZ, S., ROMAY, GONZÁLEZ, A., ARMESTO, REMIREZ, D., & MERINO, N.
- Affiliations
- Centro Nacional de Investigaciones Científicas (CU)
- ORCID
- GONZÁLEZ, RICARDO
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 39
- Issue
- 1
- Pages
- 55-59
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2122696588
- Cited by
- 220
- References
- 16
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 14 · 2018: 6 · 2017: 8 · 2016: 15 · 2015: 14 · 2014: 11 · 2013: 9 · 2012: 6
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- phycocyanin, anti-inflammatory activity, colitis, acetic acid-induced colitis, myeloperoxidase, inflammatory cell infiltration, colonic histopathology, reactive oxygen species, antioxidant activity, red algae extract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
