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Nested Case-Control Studies
Abstract
The nested case-control study design (or the case-control in a cohort study) is described here and compared with other designs, including the classic case-control and cohort studies and the case-cohort study. In the nested case-control study, cases of a disease that occur in a defined cohort are identified and, for each, a specified number of matched controls is selected from among those in the cohort who have not developed the disease by the time of disease occurrence in the case. For many research questions, the nested case-control design potentially offers impressive reductions in costs and efforts of data collection and analysis compared with the full cohort approach, with relatively minor loss in statistical efficiency. The nested case-control design is particularly advantageous for studies of biologic precursors of disease. To advance its prevention research agenda, NIH might be encouraged to maintain a registry of new and existing cohorts, with an inventory of data collected for each; to foster the development of specimen banks; and to serve as a clearinghouse for information about optimal storage conditions for various types of specimens.
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“The nested case-control design is commonly used in pharmacosurveillance research and provides estimates of effects that are consistent with those obtained from time to event analysis.67 68 69 70”
From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [67]
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Metadata
- Authors
- Ernster, V. L.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Ernster, V.L.
- Venue
- Preventive Medicine
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 23
- Issue
- 5
- Pages
- 587-590
- ISSN
- 0091-7435 (ISSN-L)
- OpenAlex
- W2013063349
- Cited by
- 299
- References
- 0
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 28 · 2023: 24 · 2022: 18 · 2021: 11 · 2020: 19 · 2019: 22 · 2018: 11 · 2017: 14 · 2016: 14 · 2015: 9 · 2014: 12 · 2013: 10 · 2012: 9
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Preventive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- nested case-control design, case-control study, cohort studies, case-cohort study, matched controls, statistical efficiency
- MeSH terms
- Humans, Preventive Medicine, Cohort Studies, Case-Control Studies
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