Pre- and postnatal oral toxicity of vinclozolin in Wistar and Long-Evans rats
Abstract
Vinclozolin administered to pregnant Wistar and Long-Evans rats from day 14 postcoitum to day 3 postpartum at 200 mg/kg body wt/day was maternally toxic (reduced food consumption and body weight gain) and increased perinatal mortality; major adverse effects on sex-specific organs in male offspring were seen (reduced anogenital distance and index; persistence of nipples/areolas into adulthood; hypospadic penis; penile hypoplasia or development of a vaginal pouch; transient paraphimosis; hypoplasia and chronic inflammation of epididymides, prostate, seminal vesicles, and coagulating glands; and also testicular tubular atrophy and chronic inflammation of the urinary bladder in some Long-Evans) with isolated inflammation-related deaths due to pyelonephritis. At 12 mg/kg, prevalence of female areola/nipple anlagen in immature (preweaning) male offspring was increased in both strains; these persisted to adulthood in a few treated Long-Evans but not Wistar offspring. Adult Long-Evans but not Wistar at this dose also had hypoplasia of prostate, seminal vesicles, and coagulating glands, and a minority had testicular tubular atrophy. The no-observed-adverse-effect levels (NOAEL) were 12 and 6 mg/kg body wt in Wistar and Long-Evans rats, respectively, in these studies. The data suggest that both the Long-Evans and the Wistar rats are comparably sensitive to the antiandrogenic effects of vinclozolin. At dose levels below the NOAEL (1 and 3 mg/kg, respectively), there were no indications…
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Perinatal exposure to Vz lowers epididymal sperm counts in adult male rats.
“adult male rats have reduced anogenital distances (AGDs), reduced seminal vesicle and ventral prostate weights, and lower epididymal sperm counts after perinatal exposure to Vz (Gray et al. 1994; Hellwig et al. 2000).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Hellwig et al. 2000
Perinatal exposure to Vz reduces anogenital distance in adult male rats.
“adult male rats have reduced anogenital distances (AGDs), reduced seminal vesicle and ventral prostate weights, and lower epididymal sperm counts after perinatal exposure to Vz (Gray et al. 1994; Hellwig et al. 2000).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Hellwig et al. 2000
Perinatal exposure to Vz reduces seminal vesicle and ventral prostate weights in adult male rats.
“adult male rats have reduced anogenital distances (AGDs), reduced seminal vesicle and ventral prostate weights, and lower epididymal sperm counts after perinatal exposure to Vz (Gray et al. 1994; Hellwig et al. 2000).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Hellwig et al. 2000
High doses of Vz are associated with measures of gross toxicity such as lowered body weights and increased mortality rate due to granulomas and bladder stones.
“High doses are associated with measures of gross toxicity such as lowered body weights and increased mortality rate due to granulomas and bladder stones (Gray et al. 1994; Hellwig et al. 2000).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Hellwig et al. 2000
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407 · see citing works
Colbert, N. K. W., Pelletier, N. C., Cote, J. M., Concannon, J. B., Jurdak, N. A., Minott, S. B., & Markowski, V. P. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7509 · Cited by 60 · see citing works
- Authors
- Hellwig, J., van Ravenzwaay, B., Mayer, M., & Gembardt, C.
- Affiliations
- BASF (Germany) (DE)
- Venue
- Regulatory Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 32
- Issue
- 1
- Pages
- 42-50
- ISSN
- 0273-2300 (ISSN-L)
- OpenAlex
- W2005961817
- Cited by
- 73
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 5 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 4
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Regulatory Toxicology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- vinclozolin, oral toxicity, prenatal exposure, perinatal toxicity, maternal toxicity, antiandrogenic effects, anogenital distance, hypospadias, cystitis, pyelonephritis, no-observed-adverse-effect level, strain differences, Wistar rats, Long-Evans rats
- MeSH terms
- Administration, Oral, Androgen Antagonists, Animals, Animals, Newborn, Female, Fetal Death, Fungicides, Industrial, Genitalia, Male, Male, Organ Size, Oxazoles, Pregnancy, Prenatal Exposure Delayed Effects, Sex Characteristics, Species Specificity, Rats, Sprague-Dawley, Toxicity Tests, No-Observed-Adverse-Effect Level, Rats, Long-Evans, Fetal Weight, Rats
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