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Polioviruses with Natural Recombinant Genomes Isolated from Vaccine-Associated Paralytic Poliomyelitis
Abstract
To determine how oral poliovirus vaccine (Sabin) strains evolve during replication in humans and to confirm the etiology of vaccine-associated paralytic poliomyelitis (VAPP), we examined 70 vaccine-derived strains isolated from VAPP cases. Two distant sequences of the poliovirus genome were targeted for a double restriction fragment length polymorphism assay (RFLP) of reverse-transcribed genomic segments amplified by PCR, an extension of the method that we described previously (Balanant et al., 1991). One (RFLP-1) was a 480-long nucleotide sequence coding for the N-terminal part of the VP1 capsid polypeptide, situated in the 5' third of the viral genome (nucleotides 2401-2880). The other (RFLP-3D1) was a 291-long nucleotide sequence coding for a part of the viral polymerase, situated near the 3' end of the genome (nucleotides 6086-6376). Strain-specific restriction profiles could be generated for different field isolates by using three restriction enzymes in each case: HaeIII, DdeI, and HpaII for RFLP-1 and HaeIII, DdeI and RsaI for RFLP-3D1. With few exceptions, the vaccine-specific RFLP profiles were found to be conserved in both regions during replication of these viruses in humans. Thus, RFLP could be used as a marker so as to identify the origin of viral isolates at both ends of their genome. Whether viral isolates were vaccine-derived was determined by using strain-specific monoclonal antibodies and RFLP-1. Among the 70 isolates, 21 of the 43 type 2 strains and 15 of the 22 type 3 strains had a recombinant genome. None of the 5 type 1 Sabin-derived isolates was found to be recombinant. Both intertypic vaccine/vaccine and vaccine/non-vaccine recombinants were detected. Partial nucleotide sequencing confirmed the RFLP results in all cases that were investigated. In one case, it was possible to predict the recombination junction site from the restriction profiles. This site was more precisely localized by sequencing. The C6203 > U nucleotide substitution, which is suspected to contribute to the reversion toward neurovirulence of the attenuated Sabin 1 strain, was detected in almost all the recombinant genomes containing Sabin 1-specific sequences at the 3' extremity. This mutation was detected by identification of the modified RsaI profile in the RFLP-3D1. The results presented in this paper suggest that recombination, alone or together with mutation, might be one of the mechanisms of the reversion toward neurovirulence of attenuated vaccine strains and of the natural evolution of poliovirus.
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“Many isolates from VAPP cases, AFP cases with incidental isolation of vaccine-related virus (much more frequent thanVAPPcases),andhealthyOPVrecipients are vaccine/vaccine recombinants (18, 33, 59, 91, 106).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [59]
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Pliaka, V., Kyriakopoulou, Z., Tsakogiannis, D., Ruether, I. G. A., Gartzonika, C., Levidiotou-Stefanou, S., Krikelis, A., & Markoulatos, P. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-1033-9 · Cited by 7
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“Some cases of acute flaccid paralysis, vaccine associated paralytic poliomyelitis (VAPP) have been described with vaccine strains as reported by Furione et al. (1993) and Georgescu et al. (1995).”
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Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005)
Dynamics of genomic variation in poliovirus in Africa
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Ανασυνδυασμένα στελέχη πολιοϊών - θέσεις γενετικού ανασυνδυασμού
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Ibrahim, W. (2014) · doi:10.70675/e87c64e6z43f4z4f83z90bdz31d1f8f18191
“La recombinaison entre PV vaccinal et souches sauvages a également été mise en évidence (Lipskaya et al., 1991 ; Furione et al., 1993 ; Georgescu et al., 1995 ; Li et al., 1996 ; Guillot et al., 2000 ; Dahourou et al., 2002) ; elle contribue à la dérive génétique des souches vaccinales et participe au moins dans certa…”
BackgroundInfluential
Metadata
- Authors
- Furlone, M., Guillot, S., Otelea, D., Balanant, J., Candrea, A., & Crainic, R.
- Affiliations
- Institut Pasteur (FR)
- ORCID
- Guillot, Sophie
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 196
- Issue
- 1
- Pages
- 199-208
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W2062555317
- Cited by
- 148
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 7 · 2013: 5 · 2012: 5
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- vaccine-associated paralytic poliomyelitis, oral polio vaccine, Sabin strains, vaccine-derived poliovirus, restriction fragment length polymorphism, strain-specific markers, live attenuated vaccine
- MeSH terms
- Base Sequence, DNA, Viral, Humans, Molecular Sequence Data, Paralysis, Poliomyelitis, Poliovirus Vaccine, Oral, Recombination, Genetic, Polymorphism, Restriction Fragment Length, Sequence Homology, Nucleic Acid, Vaccines, Synthetic, Virus Replication, Polymerase Chain Reaction, Genome, Viral, Poliovirus
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