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Simian foamy virus type 1 contains a second promoter located at the 3’ end of the Env gene
Abstract
Simian foamy virus type 1 (SFV-1) is a member of a distinct subfamily of retroviruses that possess a complex genome organization as well as complex means of regulating gene expression. This virus encodes a transcriptional transactivator (taf) that dramatically increases gene expression directed by the viral long terminal repeat. In this report, the identification of a second promoter which is significantly transactivated by SFV-1 Taf is described. The second promoter is located at the 3' end of SFV-1 env gene downstream from position 8158 (1 represents the first nucleotide sequence of the viral genome). Deletion analysis indicated that there are at least two targets for Taf in the internal promoter. A time-course analysis of SFV-1 gene expression showed that the messages for the regulatory genes were generated prior to the transcription of the structural proteins. Therefore, SFV-1 replication may be regulated by mechanisms that involve a temporal pattern of gene expression. The potential role of the internal promoter in SFV-1 gene expression and replication is discussed.
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In the citing paper
“Similar to MMTV, the basal activity of the IP is stronger than the LTR promoter due to the presence of an NRE in the LTR promoter.”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Mergia 1994
In the citing paper
“Interestingly, Tas can activate both the LTR and IPs using cis-acting response elements, an activity that is tissue specific (Löchelt et al. 1993, Campbell et al. 1994, Mergia 1994, Wei et al. 2022).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Mergia 1994
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Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication
Jehad, M. A., Ali, L. M., Pillai, V. N., Prabhu, S. G., Mustafa, F., & Rizvi, T. A. (2026) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf066 · Cited by 5
“Interestingly, Tas can activate both the LTR and IPs using cis -acting response elements, an activity that is tissue specific (Löchelt et al. 1993 , Campbell et al. 1994 , Mergia 1994 , Wei et al. 2022 ).”
Metadata
- Authors
- Mergia, A.
- Affiliations
- University of Florida (US)
- Corresponding author
- Mergia, Ayalew
- ORCID
- Mergia, Ayalew
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 1994-02
- Volume
- 199
- Issue
- 1
- Pages
- 219-222
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W1992973966
- Cited by
- 47
- References
- 0
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2019: 2 · 2018: 1 · 2015: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Virology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai030525-05)
- National Institute of Allergy and Infectious Diseases (AI30525)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- internal promoter, env gene, viral gene expression regulation, retroviral replication, temporal gene expression, long terminal repeat
- MeSH terms
- Cell Line, Promoter Regions, Genetic, Genes, env, Gene Expression Regulation, Viral, Spumavirus
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Simian foamy virus type 1 contains a second promoter located at the 3’ end of the Env gene. https://app.cochat.ai/papers/10.1006/viro.1994.1114
- The paper
- Mergia, A. (1994). Simian foamy virus type 1 contains a second promoter located at the 3’ end of the Env gene. Virology. https://doi.org/10.1006/viro.1994.1114
