Cited by 146T-cell and B-cell ImmunologySystemic Lupus Erythematosus Researchvaccines and immunoinformatics approaches

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Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept

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Oldstone, M. B. A.·2005·Current Topics in Microbiology and Immunology

DOI 10.1007/3-540-30791-5_1PMC PMC7120699

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Abstract

Molecular mimicry is defined as similar structures shared by molecules from dissimilar genes or by their protein products. Either several linear amino acids or their conformational fit may be shared, even though their origins are separate. Hence, during a viral or microbe infection, if that organism shares cross-reactive epitopes for B or T cells with the host, then the response to the infecting agent will also attack the host, causing autoimmune disease. A variation on this theme is when a second, third, or repeated infection(s) shares cross-reactive B or T cell epitopes with the first (initiating) virus but not necessarily the host. In this instance, the secondary infectious agents increase the number of antiviral/antihost effector antibodies or T cells that potentiate or precipitate the autoimmune assault. The formation of this concept initially via study of monoclonal antibody or clone T cell cross-recognition in vitro through its evolution to in vivo animal models and to selected human diseases is explored in this mini-review.

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Authors: Oldstone, M. B. A.
Affiliations: Scripps Research Institute (US)
Corresponding author: Oldstone, M. B. A.
ORCID: Oldstone, M. B. A.
Venue: Current Topics in Microbiology and Immunology
Publisher: Springer Berlin Heidelberg
Published: 2005
Volume: 296
Pages: 1-17
ISSN: 0070-217X (ISSN-L)
DOI: 10.1007/3-540-30791-5_1
PMC: PMC7120699
OpenAlex: W96814828
Cited by: 146
References: 53
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 13 · 2013: 17 · 2012: 6
FWCI: 8.50
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current topics in microbiology and immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI045927, R01AI045927, AI036222, R01AI036222, AI-009484)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058541, DK-058541)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords: molecular mimicry, autoimmune disease, microbial infection, cross-reactive epitopes, B-cell epitopes, T cell epitopes, viral infection, secondary infection, autoimmunity, monoclonal antibodies, animal models of autoimmunity
MeSH terms: Amino Acid Sequence, Animals, Epitopes, Autoantibodies, Autoantigens, Autoimmune Diseases, Disease Models, Animal, Humans, Infections, Molecular Sequence Data, T-Lymphocytes, Models, Immunological, Molecular Mimicry

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Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept

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