Oncogenic Roles of the PI3K/AKT/mTOR axis

Aoki, Masahiro, Fujishita, Teruaki·2017·Current topics in microbiology and immunology

Cites (228)

Items 201–229 of 229

  1. Opposing Effects of Androgen Deprivation and Targeted Therapy on Prostate Cancer Prevention
    Shidong Jia, Xueliang Gao, Sang‐Hyun Lee, Sauveur-Michel Maira, Xiaoqiu Wu, Edward C. Stack, Sabina Signoretti, Massimo F. Loda, Jean J. Zhao, Thomas M. Roberts · 2012 · Cancer Discovery
  2. Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML
    Sewa Rijal, Shaun A. Fleming, Nik Cummings, Natalie K. Rynkiewicz, Lisa M. Ooms, Nhu-Y. N. Nguyen, Tse‐Chieh Teh, Sharon Avery, Julie F. McManus, Anthony T. Papenfuss et al. · 2015 · Blood
  3. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α
    Kira Gritsman, Haluk Yuzugullu, Thanh Von, Howard Yan, Linda K. Clayton, Christine M. Fritsch, Sauveur-Michel Maira, Gregory J. Hollingworth, Christine H. Choi, Tulasi Khandan et al. · 2014 · Journal of Clinical Investigation
  4. INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia
    Irakli Dzneladze, Ruijuan He, John F. Woolley, Meong Hi Son, Mark Sharobim, Shayne Aaron Greenberg, Martino Gabra, C Langlois, A Rashid, Anne Hakem et al. · 2015 · Leukemia
  5. A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis
    Haluk Yuzugullu, Lukas Baitsch, Thanh Von, Allison Steiner, Haoxuan Tong, Jing Ni, Linda K. Clayton, Roderick Terry Bronson, Thomas M. Roberts, Kira Gritsman et al. · 2015 · Nature Communications
  6. Mutations in Critical Domains Confer the Human mTOR Gene Strong Tumorigenicity*
    Avaniyapuram Kannan Murugan, Ali Saeed Alzahrani, Mingzhao Xing · 2013 · Journal of Biological Chemistry
  7. Translation Initiation Factor 4E Blocks Endoplasmic Reticulum-mediated Apoptosis
    Shunan Li, D. Perlman, Mark S. Peterson, David Burrichter, Svetlana V. Avdulov, Vitaly A. Polunovsky, Peter B. Bitterman · 2004 · Journal of Biological Chemistry
  8. Mutationally Activated PIK3CAH1047R Cooperates with BRAFV600E to Promote Lung Cancer Progression
    Christy L. Trejo, Shon Green, Victoria L. Marsh, Eric Andrew Collisson, Gioia Iezza, Wayne Allen Phillips, Martin McMahon · 2013 · Cancer Research
  9. Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer
    Carmen Blanco‐Aparicio, Lucía Pérez-Gallego, Belén Pequeño, Juan Fernando Martínez-Leal, Oliver Renner, Amancio Carnero · 2006 · Carcinogenesis
  10. Hymyc1 Downregulation Promotes Stem Cell Proliferation in Hydra vulgaris
    Alfredo Ambrosone, Valentina Marchesano, Angela Tino, Bert Hobmayer, Claudia Tortiglione · 2012 · PLoS ONE
  11. In Vitro Budding of Intralumenal Vesicles into Late Endosomes Is Regulated by Alix and Tsg101
    Thomas Falguières, Pierre‐Philippe Luyet, Christin Bissig · 2008 · HAL (Le Centre pour la Communication Scientifique Directe)
  12. PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
    Green, Shon, Trejo, Christy L., McMahon, Martin · 2015 · Cancer Research
  13. Expression of Activated PIK3CA in Ovarian Surface Epithelium Results in Hyperplasia but Not Tumor Formation
    Shun Liang, Nuo Yang, Yue Pan, Shan Deng, Xiaojuan Lin, Xiaojun Yang, Dionyssios Katsaros, Katherine F. Roby, Thomas C. Hamilton, Denise C. Connolly et al. · 2009 · PLoS ONE
  14. The effect Akt2 deletion on tumor development in Pten+/− mice
    P-Z Xu, M-L Chen, S-M Jeon, X-d Peng, Nissim Hay · 2011 · Oncogene
  15. Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse
    Caterina Nardella, Arkaitz Carracedo, Leonardo Salmena, Pier Paolo Pandolfi · 2010 · Current topics in microbiology and immunology
  16. From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development
    Saveur-Michel Maira, Peter M. Finan, Carlos Garcı́a-Echeverrı́a · 2010 · Current topics in microbiology and immunology
  17. Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer
    Hiroyuki Yamaguchi, Masahito Kawazu, Takahiko Yasuda, Manabu Soda, Toshihide Ueno, Shinya Kojima, Masakazu Yashiro, Ichiro Yoshino, Yuichi Ishikawa, Eirin Sai et al. · 2015 · Cancer Science
  18. Activated Mutant p110α Causes Endometrial Carcinoma in the Setting of Biallelic Pten Deletion
    Ayesha R. Joshi, Christopher A. Miller, Suzanne J. Baker, Lora H. Ellenson · 2015 · American Journal Of Pathology
  19. Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3
    Christian D. Young, Erica C Nolte, Andrew S. Lewis, Natalie Julie Serkova, Steven Michael Anderson · 2008 · Breast Cancer Research
  20. Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis
    Maria Mancini, Evan C. Lien, Alex Toker · 2016 · Oncotarget
  21. Physiological expression of the PI3K-activating mutation Pik3caH1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice
    Lauren Hare, Toby James Phesse, Paul Michael Waring, Karen G. Montgomery, Kathryn M. Kinross, Kevin Mills, Vincent Roh, Joan K. Heath, Robert George Ramsay, Matthias Ernst et al. · 2013 · Biochemical Journal
  22. mTOR Inhibition Elicits a Dramatic Response in PI3K-Dependent Colon Cancers
    Dustin A. Deming, Alyssa A. Leystra, Mohammed Farhoud, Laura A. Nettekoven, Linda J. Clipson, Dawn M. Albrecht, Mary Kay Washington, Ruth Sullivan, Jamey P. Weichert, Richard B. Halberg · 2013 · PLoS ONE
  23. Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors
    Carlos L. Arteaga · 2010 · Current topics in microbiology and immunology
  24. Renal tumours in a Tsc2+/− mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin
    J Yang, Maria Kalogerou, Paulina A. Samsel, Yaotian Zhang, D F R Griffiths, John Gallacher, Julian R. Sampson, Ming Hong Shen · 2014 · Oncogene
  25. AKT1E17K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer
    Donatella Malanga, Stefania Belmonte, Fabiana Colelli, Marzia Scarfò, Carmela De Marco, Duarte Mendes Oliveira, Teresa Mirante, Caterina Camastra, Monica Gagliardi, Antonia Rizzuto et al. · 2016 · PLoS ONE
  26. More Paths to PI3Kγ
    Len Stephens, Phillip T. Hawkins · 2013 · PLoS Biology
  27. [Laminin alpha3 chain-derived peptide promotes keratinocyte migration and wound closure: clustering of syndecan-4 and integrin beta1].
    Atsushi Utani · 2010 · PubMed
  28. Evaluation of mTOR function by a gain-of-function approach
    Yoichiro Ohne, Terunao Takahara, Tatsuya Maeda · 2009 · Cell Cycle
  29. Erratum: PTEN loss in the continuum of common cancers, rare syndromes and mouse models
    Mary Christine Hollander, Gideon Michael Blumenthal, Phillip A. Dennis · 2011 · Nature reviews. Cancer