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Cited by 3Mitochondrial Function and PathologyArsenic contamination and mitigationHeavy Metal Exposure and Toxicity

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Mitochondrial Toxicity of Organic Arsenicals

Liu, Yu-Jiao, Liu, Yi·2022·Methods in Molecular Biology
DOI 10.1007/978-1-0716-2309-1_11
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Abstract

Arsenic is either notorious toxicant or miracle cure for acute promyelocytic leukemia and several other diseases. It interacts with mitochondria directly or indirectly, by interacting with mitochondrial enzymes, such as respiratory chain complexes and tricarboxylic acid cycle proteins, or affecting mitochondrial homeostasis via ROS or mitochondrial outer membrane permeabilization. Given the ubiquitous presence of mitochondria and indispensable role in cellular metabolism, arsenical-mitochondrial interactions may manifest clinical importance by revealing mechanism of disease curation, preventing severe side effects, and foreseeing potential health issues. Here, we described the interaction between isolated mitochondria and arsenicals.

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Metadata

Authors
Liu, Y.-J., & Liu, Y.
Affiliations
Tiangong University (CN)
Corresponding author
Liu, Yi
ORCID
Liu, Yi
Venue
Methods in Molecular Biology
Publisher
Springer US
Published
2022
Volume
2497
Pages
173-184
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
DOI
10.1007/978-1-0716-2309-1_11
OpenAlex
W4285158663
Cited by
3
References
1
Citations by year
2023: 2 · 2022: 1
FWCI
1.26
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Methods in molecular biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
organoarsenic compounds, arsenic toxicity, mitochondria, respiratory chain complexes, TCA cycle, mitochondrial homeostasis, reactive oxygen species, mitochondrial outer membrane permeabilization, acute promyelocytic leukemia
MeSH terms
Arsenic Trioxide, Arsenicals, Mitochondria, Oxides, Apoptosis, Reactive Oxygen Species, Membrane Potential, Mitochondrial

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Liu, Y.-J., & Liu, Y. (2022). Mitochondrial Toxicity of Organic Arsenicals. Methods in Molecular Biology. https://doi.org/10.1007/978-1-0716-2309-1_11