The Bisretinoids of RPE Lipofuscin: A Complex Mixture
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The RPE also accumulates retinal condensation products, which can be detected by TPM and monitored independently from other retinoids because of their unique spectral properties.
“The RPE also accumulates other retinoids, including retinal condensation products.314,315 These metabolites also can be detected by TPM, and since they are characterized by unique spectral properties, the intracellular accumulation and distribution of these compounds can be monitored independently from other retinoids”
From Chemistry of the Retinoid (Visual) Cycle (2014) · cites this paper as [315]
The All-Trans-Retinal Dimer Series section (page unavailable) describes retinal condensation products in RPE lipofuscin and gives their distinct absorbance wavelengths. The paper does not establish that TPM detects them or that their intracellular accumulation and distribution can be monitored independently from other retinoids. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 35 · Cited by 15
Research works printed but not linked: 2
- Ben-Shabat S, Itagaki Y, Jockusch S (2002a) Formation of a nona-oxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed 41: 814– 817 12491345
- Ben-Shabat S, Parish CA, Vollmer HR (2002b) Biosynthetic studies of A2E, a major fluorophore of RPE lipofuscin. J Biol Chem 277: 7183– 7190 11756445
- Authors
- Sparrow, J. R., & Yamamoto, K.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Sparrow, Janet R.
- ORCID
- Sparrow, Janet R.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US
- Published
- 2011-11-11
- Volume
- 723
- Pages
- 761-767
- ISSN
- 0065-2598 (ISSN-L)
- PMC
- PMC11829280
- OpenAlex
- W2259914024
- Cited by
- 15
- References
- 35
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 2.06
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Research to Prevent Blindness
- National Institutes of Health
- National Eye Institute (R01EY012951, EY 12951)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- bisretinoids, lipofuscin, retinal pigment epithelium, A2E, ABCA4, age-related macular degeneration, retinal degeneration, vitamin A aldehyde, photooxidation, isomers
- MeSH terms
- Animals, Humans, Lipofuscin, Macular Degeneration, Oxidation-Reduction, Retinoids, Cellular Senescence, Retinal Pigment Epithelium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
