Neurobiology of sociability
Open accessAbstract
Sociability consists of behaviors that bring animals together and those that keep animals apart. Remarkably, while the neural circuitry that regulates these two "faces" of sociability differ from one another, two neurohormones, oxytocin (Oxt) and vasopressin (Avp), have been consistently implicated in the regulation of both. In this chapter the the structure and function of the Oxt and Avp systems, the ways in which affiliative and aggressive behavior are studied and the roles of Oxt and Avp in the regulation of sociability will be briefly reviewed. Finally, work implicating Oxt and Avp in sociability in humans, with a focus on neuropsychiatric disorders will be highlighted.
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In humans, increased functional connectivity between nodes of the ventral striatum has been reported in addiction, anxiety, lack of social motivation, and OCD.
“In humans, increase functional connectivity between nodes of the ventral striatum has been reported in addiction, anxiety, lack of social motivation, and even obsessive-compulsive disorder (OCD) (Harrison et al. 2009; Sakai et al. 2011; Caldwell 2012).”
From Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories (2018) · cites this paper as Caldwell 2012
Oxytocin has central neuromodulatory effects on social behaviors such as affiliative, aggressive, and parental behaviors.
“Oxytocin is a mammalian neurohormone composed of nine amino acids, known for its peripheral effects on parturition and lactation (5–7), as well as its central neuromodulatory effects on social behaviors such as affiliative, aggressive, and parental behaviors (8, 9).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [9]
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References 197 · Cited by 58
Research works printed but not linked: 2
- [87]Numan M Insel TR The Neurobiology of Parental Care New York Springer-Verlag 2003
- [120]Koolhaas JM Moor E Hiemstra Y The testosterone-dependent vasopressinergic neurons in the medial amygdala and lateral septum: involvement in social behaviour in male rats Proceedings of the Third International Vasopressin Conference Paris/London Colloque INSERM/John Libbey Eurotext Ltd 1991 213 219
- Authors
- Caldwell, H. K.
- Affiliations
- Kent State University (US)
- Corresponding author
- Caldwell, Heather K.
- ORCID
- Caldwell, Heather K.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US
- Published
- 2012
- Volume
- 739
- Pages
- 187-205
- ISSN
- 0065-2598 (ISSN-L)
- PMC
- PMC4146394
- OpenAlex
- W2115709422
- Cited by
- 58
- References
- 197
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 19.32
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R21MH083963, MH083963)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- sociability, oxytocin, vasopressin, affiliative behavior, aggression, neural circuits, social behavior regulation, neuropsychiatric disorders
- MeSH terms
- Animals, Mental Disorders, Humans, Neurobiology, Social Behavior, Neurotransmitter Agents
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