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TGF-β Signaling in Stem Cell Regulation
Abstract
The transforming growth factor-β (TGF-β) family of cytokines, including TGF-β, bone morphogenic proteins (BMPs), and activin/nodal, is a group of crucial morphogens in embryonic development, and plays key roles in modulating stem/progenitor cell fate. TGF-β signaling is essential in maintaining the pluripotency of human pluripotent stem cells (hPSCs), including both human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), and its modulation can direct lineage-specific differentiation. Recent studies also demonstrate TGF-β signaling negatively regulates reprogramming and inhibition of TGF-β signaling can enhance reprogramming through facilitating mesenchymal-to-epithelial transition (MET). This chapter introduces methods of modulating somatic cell reprogramming to iPSCs and neural induction from hPSCs through modulating TGF-β signaling by chemical approaches.
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Vitamin C, IL-6, TGFβ and bone morphogenetic proteins regulate cellular reprogramming by affecting DNA methylation levels, thereby adjusting the expression of certain microRNAs or facilitating the mesenchymal-to-epithelial transition (MET).
“In addition to cell intrinsic transcription factors for cellular reprogramming, modulators such as vitamin C [62][63][64][65] , IL-6 [66][67][68] , TGFβ 69 and bone morphogenetic proteins 70 have been shown to regulate cellular reprogramming by affecting DNA methylation levels, thereby adjusting the expression of certain microRNAs or facilitating the mesenchymal-to-epithelial transition (MET).”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [69]
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Research works printed but not linked: 11
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Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Cipriano, A., Moqri, M., Maybury-Lewis, S. Y., Rogers-Hammond, R., de Jong, T. A., Parker, A., Rasouli, S., Schöler, H. R., Sinclair, D. A., & Sebastiano, V. (2023) · Nature Aging · doi:10.1038/s43587-023-00539-2 · Cited by 66
Metadata
- Authors
- Li, W., Wei, W., & Ding, S.
- Venue
- Methods in Molecular Biology
- Publisher
- Springer New York
- Published
- 2016
- Pages
- 137-145
- ISSN
- 1064-3745
- 1940-6029
- Cited by
- 14
- References
- 0
- Language
- en
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