MicroRNAs: biomarkers, diagnostics, and therapeutics
Abstract
MicroRNAs (miRNAs) are small noncoding RNAs (21-23 nucleotides in length) that regulate gene expression at translational or posttranslational levels. The major regulatory mechanisms include translational repression or mRNA degradation (Filipowicz et al., Curr Opin Struct Biol 15:331-341, 2005).Aberrant expression of miRNAs has been found to be associated with a variety of human diseases such as cancers/tumors, diabetes, viral infections, cardiovascular diseases, neurodegenerative diseases, and other diseases (Wang et al., J Cell Physiol 23:25-30, 2016; Lawrie, MicroRNAs in medicine, 2013). The expression of miRNAs is tissue specific and can be used to identify tumor type and its origin (Mishra and Merlino, J Clin Invest 119:2119-2123, 2009). Many investigations suggest that the miRNA-expression profiles are novel diagnostic and prognostic biomarkers for multiple human diseases. Manipulating relevant miRNA expression or function may serve as potential therapeutic strategies for different diseases.
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Extracellular miRNAs function as chemical messengers to mediate cell-cell communication.
“Extracellular miRNAs function as chemical messengers to mediate cell-cell communication.”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [23]
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References 70 · Cited by 237
- Authors
- Huang, W.
- Corresponding author
- Huang, Weili
- Venue
- Methods in molecular biology
- Publisher
- Springer New York
- Published
- 2017
- Volume
- 1617
- Pages
- 57-67
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W2618175351
- Cited by
- 237
- References
- 70
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 28 · 2023: 31 · 2022: 48 · 2021: 55 · 2020: 23 · 2019: 12 · 2018: 8 · 2017: 3
- FWCI
- 10.12
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, biomarkers, disease diagnosis, prognostic factors, miRNA expression profiling, protein synthesis inhibition, post-transcriptional regulation, cancer, miRNA-based therapy, tissue-specific miRNA expression
- MeSH terms
- Animals, Cardiovascular Diseases, Diabetes Mellitus, Gene Expression Regulation, Humans, Neoplasms, Prognosis, Virus Diseases, Biomarkers, Neurodegenerative Diseases, MicroRNAs
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