Lupus Anticoagulant Testing: Diluted Russell Viper Venom Time (dRVVT)
Abstract
Diluted Russell Viper Venom Time (dRVVT) has become the most popular test to detect Lupus Anticoagulant (LA). dRVVT is more sensitive than other global tests employed to detect LA and is not affected by inhibitors of factor VIII or IX. The test is most successfully implemented if you observe three steps in its execution: screening, mixing, and confirmatory studies. Interference due to the presence of heparin in tested plasma must be excluded by means of thrombin time (TT). The prior use of Vitamin K Antagonists (VKAs) or Non-vitamin K Oral Anticoagulants (NOACs) must also be evaluated by means of International Normalized Ratio, or specific tests, respectively.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the literature, dRVVT is described as the most specific, sensitive, and robust test to detect LA.
“In the literature, dRVVT is described as the most specific, sen sitive, and robust test to detect LA. 24”
From Single or triple positivity for antiphospholipid antibodies in “carriers” or symptomatic patients: Untangling the knot (2021) · cites this paper as [24]
The citation lists haven’t been fetched yet
References 24 · Cited by 21
- Authors
- Pengo, V., Bison, E., Banzato, A., Zoppellaro, G., Jose, S. P., & Denas, G.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Pengo, Vittorio
- Venue
- Methods in Molecular Biology
- Publisher
- Springer New York
- Published
- 2017
- Volume
- 1646
- Pages
- 169-176
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W2744523655
- Cited by
- 21
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 9.22
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- lupus anticoagulant, anticoagulant screening, mixing studies, confirmatory testing, thrombin time, heparin interference, factor VIII inhibitors, factor IX inhibitors, vitamin K antagonists, direct oral anticoagulants, international normalized ratio
- MeSH terms
- Administration, Oral, Anticoagulants, Humans, Prothrombin Time, Quality Control, Reference Values, Thrombin Time, Vitamin K, Lupus Coagulation Inhibitor, International Normalized Ratio
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
