Performance and interpretation of mixing tests in coagulation
Abstract
Mixing tests in coagulation studies allow the laboratory to correctly differentiate factor deficiency from inhibitors as the cause of a prolonged clotting time. This is important in terms of subsequent laboratory follow-up and clinical patient management. In this chapter, a suggested method of performing mixing tests is given, with procedures applying two different formulas for interpretation, the percent correction and the index of circulating anticoagulant.
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The mixing test is useful to investigate the cause of unexpectedly prolonged activated partial thromboplastin time (APTT).
“The mixing test is useful to investigate the cause of unexpectedly prolonged activated partial thromboplastin time (APTT).”
Numerical indexes are reportedly useful in observed correction.
“Because the correction/non-correction interpretation is subjective, numerical indexes are reportedly useful in observed correction [[1], [2], [3], [4], [5]].”
Theoretically, mixing tests would show non-correction under coexistence of factor deficiency and LA.
“Theoretically, the mixing tests would show non-correction [2] because despite adding NPP to overcome factor deficiency, the presence of LA persists.”
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References 8 · Cited by 16
- Authors
- Kershaw, G.
- Affiliations
- Royal Prince Alfred Hospital (AU)
- Corresponding author
- Kershaw, Geoffrey
- ORCID
- Kershaw, Geoffrey
- Venue
- Methods in molecular biology
- Publisher
- Springer New York
- Published
- 2017
- Volume
- 1646
- Pages
- 85-90
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W2745226133
- Cited by
- 16
- References
- 8
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2019: 4 · 2018: 1 · 2017: 2
- FWCI
- 5.92
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Hemophilia Treatment and Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- mixing test, coagulation tests, factor deficiency, anticoagulants, prolonged clotting time, coagulation factor assays
- MeSH terms
- Blood Coagulation, Humans, Partial Thromboplastin Time, Prothrombin Time, Coagulation Protein Disorders
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