The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pharmacological Inhibition of Endocytic Pathways: Is It Specific Enough to Be Useful?
Abstract
Eukaryotic cells constantly form and internalize plasma membrane vesicles in a process known as endocytosis. Endocytosis serves a variety of housekeeping and specialized cellular functions, and it can be mediated by distinct molecular pathways. Among them, internalization via clathrin-coated pits, lipid raft/caveolae-mediated endocytosis and macropinocytosis/phagocytosis are the most extensively characterized. The major endocytic pathways are usually distinguished on the basis of their differential sensitivity to pharmacological/chemical inhibitors, although the possibility of nonspecific effects of such inhibitors is frequently overlooked. This review provides a critical evaluation of the selectivity of the most widely used pharmacological inhibitors of clathrin-mediated, lipid raft/caveolae-mediated endocytosis and macropinocytosis/phagocytosis. The mechanisms of actions of these agents are described with special emphasis on their reported side effects on the alternative internalization modes and the actin cytoskeleton. The most and the least-selective inhibitors of each major endocytic pathway are highlighted.
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Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
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Mechanisms of Statin-mediated Inhibition of Small G-protein Function
Cordle, A., Koenigsknecht-Talboo, J., Wilkinson, B., Limpert, A., & Landreth, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505268200 · Cited by 235
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Cited by
Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683
Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Sousa de Almeida, M., Susnik, E., Drasler, B., Taladriz-Blanco, P., Petri-Fink, A., & Rothen-Rutishauser, B. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01127d · Cited by 1,079
Costa Verdera, H., Gitz-Francois, J. J., Schiffelers, R. M., & Vader, P. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.019 · Cited by 554
In vitro and in vivo characterization of pharmaceutical nanocarriers used for drug delivery
Jain, A. K., & Thareja, S. (2019) · Artificial Cells, Nanomedicine, and Biotechnology · doi:10.1080/21691401.2018.1561457 · Cited by 319
Metadata
- Authors
- Ivanov, A. I.
- Venue
- Methods in Molecular Biology
- Publisher
- Humana Press
- Published
- 2008
- Volume
- 440
- Pages
- 15-33
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W1319875
- Cited by
- 601
- References
- 5
- FWCI
- 47.56
- Type
- book chapter
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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