Rat models of cardiovascular diseases
Abstract
In cardiovascular research, the rat has been the main model of choice for decades. Experimental procedures were developed to generate cardiovascular disease states in this species, such as systemic and pulmonary hypertension, cardiac hypertrophy and failure, myocardial infarction, and stroke. Furthermore, rats have been bred, which spontaneously develop such diseases. They became extremely valuable models to understand the genetics of these diseases, since powerful genomic tools are now available for the rat. One of these tools is transgenic technology, which has allowed the creation of even more disease models in the rat. This review summarizes the experimental, genetic, and transgenic rat models for cardiovascular diseases.
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The rat is particularly amenable to measurements of cognitive-behavioral, endocrine, muscle, and cardiovascular endpoints, and extensive historical data exist on physiological changes with aging.
“The rat is particularly amendable to measurements of cognitive-behavioral, endocrine (e.g., glucose tolerance), muscle, and cardiovascular endpoints, and there is extensive historical data on physiological changes with aging [42–46].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [42]
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References 86 · Cited by 63
- Authors
- Bader, M.
- Venue
- Methods in Molecular Biology
- Publisher
- Humana Press
- Published
- 2009-10-28
- Volume
- 597
- Pages
- 403-414
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W117213378
- Cited by
- 63
- References
- 86
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 11 · 2018: 1 · 2017: 3 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 29.40
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- rat model, cardiovascular disease, systemic hypertension, pulmonary hypertension, cardiac hypertrophy, heart failure, myocardial infarction, stroke, transgenic rats, genetic disease models, rat genetics
- MeSH terms
- Animals, Cardiovascular Diseases, Disease Models, Animal, Cardiomegaly, Humans, Hypertension, Models, Genetic, Myocardial Infarction, Stroke, Rats, Rats, Transgenic
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