The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Polymeric Nanoparticles for Drug Delivery
Abstract
The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significant therapeutic potential. Concurrently, targeted delivery technologies are becoming increasingly important as a scientific area of investigation. In cancer, targeted polymeric NPs can be used to deliver chemotherapies to tumor cells with greater efficacy and reduced cytotoxicity on peripheral healthy tissues. In this chapter, we describe the methods of (1) preparation and characterization of drug-encapsulated polymeric NPs formulated with biocompatible and biodegradable poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-b-PEG) copolymers; (2) surface functionalization of the polymeric NPs with the A10 2'-fluoropyrimidine ribonucleic acid (RNA) aptamers that recognize the prostate-specific membrane antigen (PSMA) on prostate cancer cells; and (3) evaluation of the binding properties of these targeted polymeric NPs to PSMA-expressing prostate cancer cells in vitro and in vivo. These methods may contribute to the development of other useful polymeric NPs to deliver a spectrum of chemotherapeutic, diagnostic, and imaging agents for various applications.
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Citations
Cites
Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery
Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., & Farokhzad, O. C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.047 · Cited by 1,273
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Cited by
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
Self-citationTargeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,730
Self-citationAbbasi, R., Shineh, G., Mobaraki, M., Doughty, S., & Tayebi, L. (2023) · Journal of Nanoparticle Research · doi:10.1007/s11051-023-05690-w · Cited by 623
Stimuli‐responsive liposomes for drug delivery
Lee, Y., & Thompson, D. H. (2017) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1450 · Cited by 579
Polymeric nanoparticles for targeted treatment in oncology: current insights
Joshi, M. D., Patravale, V., & Prabhu, R. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s56932 · Cited by 438
Metadata
- Authors
- Chan, J. M., Valencia, P. M., Zhang, L., Langer, R., & Farokhzad, O. C.
- Venue
- Methods in Molecular Biology
- Publisher
- Humana Press
- Published
- 2010
- Volume
- 624
- Pages
- 163-175
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W1841920392
- Cited by
- 339
- References
- 1
- FWCI
- 14.73
- Type
- book chapter
- Language
- en
- Open access
- closed
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- Chan, J. M., Valencia, P. M., Zhang, L., Langer, R., & Farokhzad, O. C. (2010). Polymeric Nanoparticles for Drug Delivery. Methods in Molecular Biology. https://doi.org/10.1007/978-1-60761-609-2_11
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