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cGMP-Dependent Protein Kinases (cGK)

Hofmann, Franz, Wegener, Jörg W.·2013·Methods in Molecular Biology
DOI 10.1007/978-1-62703-459-3_2
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Abstract

cGMP-dependent protein kinases (cGK) are serine/threonine kinases that are widely distributed in eukaryotes. Two genes-prkg1 and prkg2-code for cGKs, namely, cGKI and cGKII. In mammals, two isozymes, cGKIα and cGKIβ, are generated from the prkg1 gene. The cGKI isozymes are prominent in all types of smooth muscle, platelets, and specific neuronal areas such as cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. The cGKII prevails in the secretory epithelium of the small intestine, the juxtaglomerular cells, the adrenal cortex, the chondrocytes, and in the nucleus suprachiasmaticus. Both cGKs are major downstream effectors of many, but not all, signalling events of the NO/cGMP and the ANP/cGMP pathways. cGKI relaxes smooth muscle tone and prevents platelet aggregation, whereas cGKII inhibits renin secretion, chloride/water secretion in the small intestine, the resetting of the clock during early night, and endochondral bone growth. This chapter focuses on the involvement of cGKs in cardiovascular and non-cardiovascular processes including cell growth and metabolism.

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Metadata

Authors
Hofmann, F., & Wegener, J. W.
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2013
Pages
17-50
ISSN
  • 1064-3745
  • 1940-6029
DOI
10.1007/978-1-62703-459-3_2
Cited by
57
References
4
Language
en
Licence

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